Publications by authors named "Ali Alsharqi"
: Nonsurgical periodontal treatment (NSPT) is the gold-standard technique for treating periodontitis. However, an individual's susceptibility or the inadequate removal of subgingival biofilms could lead to unfavorable responses to NSPT. This study aimed to assess the potential of salivary and microbiological biomarkers in predicting the site-specific and whole-mouth outcomes of NSPT.
View Article and Find Full Text PDFThis study investigates the impact of nonsurgical periodontal treatment (NSPT) on oral health-related quality of life (OHRQoL) in patients with periodontitis stages (S)2 and S3, and the factors associated with the prediction of patient-reported outcomes. Periodontitis patients (n = 68) with moderately deep periodontal pockets were recruited. Responses to the Oral Health Impact Profile (OHIP)-14 questionnaire and clinical parameters including plaque index, bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment loss (CAL) were recorded.
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- The dental plaque biofilm is a key factor in starting and worsening periodontal disease, composed of various microorganisms in an organized structure.
- The early theory suggested that just having more plaque leads to disease, but recent research shows that it’s more complex, involving interactions between bacteria and the host immune system.
- Not all bacteria in the biofilm are harmful; some are beneficial and help maintain a healthy balance, which prevents disease progression and influences broader health issues.
Article Synopsis
- Variation in response to biologic therapy for inflammatory diseases, like psoriasis, is influenced by how much of the drug reaches the patient (drug exposure).
- Real-world data from a study with 491 patients receiving ustekinumab was analyzed to create a pharmacokinetic/pharmacodynamic (PK/PD) model, looking at different dosing strategies.
- The study identified a group of potential nonresponders and suggested that the model could be used in the future to personalize drug dosing through a monitoring system, aiming to enhance treatment effectiveness.
Importance: High-cost biologic therapies have transformed the management of immune-mediated inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by measurement of circulating drug levels has been shown to be effective in various settings. However, limited evidence exists for this approach with the interleukin 12 and interleukin 23 inhibitor ustekinumab.
View Article and Find Full Text PDFBackground: Biologic therapies can be highly effective for the treatment of severe psoriasis, but response for individual patients can vary according to drug. Predictive biomarkers to guide treatment selection could improve patient outcomes and treatment cost-effectiveness.
Objective: We sought to test whether HLA-C*06:02, the primary genetic susceptibility allele for psoriasis, predisposes patients to respond differently to the 2 most commonly prescribed biologics for psoriasis: adalimumab (anti-TNF-α) and ustekinumab (anti-IL-12/23).
The rising demand for dermatology services calls for more -efficient clinics. However, there is a lack of evidence to guide the allocation of time for dermatological consultations. Our study analysed 607 dermatology consultations led by 23 clinicians.
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- Phototherapy is a proven treatment for skin disorders in both adults and children, with success in conditions like atopic dermatitis and psoriasis.
- A study reviewed 75 children (ages 3-17) who received phototherapy at a dermatology center, primarily using narrowband ultraviolet B (NBUVB) and some using psoralen and ultraviolet A (PUVA).
- After treatment, 76% of atopic dermatitis patients and 86% of psoriasis patients showed significant skin improvement, with notable persistence of results at the 12-month follow-up, suggesting phototherapy as an effective option when standard treatments fail.
Background/objectives: The simplified psoriasis index (SPI) is a three-part multidimensional tool incorporating disease severity, psychosocial impact and historical course completed by the health-care professional (professional SPI, [proSPI]) or the patient (self-assessment SPI, [saSPI]). We aimed to assess the validity and response distribution of proSPI and saSPI in patients with psoriasis undergoing phototherapy.
Methods: The validity and response distribution of SPI was assessed by recording saSPI and proSPI in patients with psoriasis before and after a course of phototherapy.
Cutaneous Mastocytosis is not an uncommon condition in the pediatric setting. The eruption can have multiple clinical presentations. We present a case of a 3-month-old child with a solitary mastocytoma who was initially diagnosed with recurrent bullous impetigo.
View Article and Find Full Text PDFBackground: Multiple modalities are available for treating acne scars, one of which is chemical peeling.
Objective: To evaluate the efficacy of medium-depth peels in the treatment of acne scars.
Methods: A total of 15 patients (14 women and 1 man) were seen between November 1998 and March 2000.