A Case Report of 17α-Hydroxylase Deficiency in Two Saudi Siblings With Different Karyotyping.

Congenital adrenal hyperplasia (CAH) consists of variable disorders of sex determination and differentiation. 17α-hydroxylase deficiency (17OHD) is an uncommon form of those disorders, which is typically characterized by hypertension, hypokalemia, failure of puberty, and ambiguous genitalia. The 17α-hydroxylase enzyme is encoded by the CYP17A1 gene and it is required for the synthesis of cortisol and sex steroids.

Cancer Research in Vulnerable Populations: A Call for Collaboration and Sustainability From MENAT Countries.

Purpose: Cancer is a major burden across Middle East, North Africa, Türkiye (MENAT). Many MENAT countries experience multiple conflicts that compound vulnerabilities, but little research investigates the linkages between vulnerability and cancer research. This study examines the current level and the potential for cancer research among vulnerable populations in the MENAT region, aiming to provide direction toward developing a research agenda on the region's vulnerable populations.

Use of camel urine is of no benefit to cancer patients: observational study and literature review.

Background: Complementary and alternative medicine is widely used in Saudi Arabia. One of the common practices is the use of camel urine alone or mixed with camel milk for the treatment of cancer, which is often supported by religious beliefs.

Aims: To observe and follow-up cancer patients who insisted on using camel urine, and to offer some clinically relevant recommendations.

How does Linkage to the National Death Index Affect Population-Based Net Survival Estimates for Women with Cervical Cancer in Saudi Arabia?

Background: Population-based cancer survival is a key metric for the assessment of cancer control strategies. Accurate estimation of cancer survival requires complete follow-up data for all patients.

Aim: To explore the impact of linking national cancer registry data to the national death index on net survival estimates for women diagnosed with cervical cancer in Saudi Arabia during 2005-2016.

Increased Prevalence of EBV Infection in Nasopharyngeal Carcinoma Patients: A Six-Year Cross-Sectional Study.

Epstein Barr Virus (EBV) is implicated in the carcinogenesis of nasopharyngeal carcinoma (NPC) and currently associated with at least 1% of global cancers. The differential prognosis analysis of NPC in EBV genotypes remains to be elucidated. Medical, radiological, pathological, and laboratory reports of 146 NPC patients were collected retrospectively over a 6-year period between 2015 and 2020.

Case report: A fatal outcome from co-infection of COVID-19 and dengue in the western region of Jeddah, Saudi Arabia.

Introduction: Co-infection of coronavirus disease 2019 (COVID-19) and dengue may coexist, as both viruses share similar laboratory and clinical features, making diagnosis and treatment challenging for health care professionals to prescribe, negatively impacting patient prognosis, and outcomes.

Results And Discussions: Both cases were positive for PCR and X-ray laboratory investigation at clinical examination, confirming COVID-19 and dengue co-infection, admission, and better management in referral hospitals are presented and discussed. The timeline provides detailed cases of situational analysis and the medical actions taken, as well as the outcomes.

Tracking Missing Person in Large Crowd Gathering Using Intelligent Video Surveillance.

Locating a missing child or elderly person in a large gathering through face recognition in videos is still challenging because of various dynamic factors. In this paper, we present an intelligent mechanism for tracking missing persons in an unconstrained large gathering scenario of Al-Nabawi Mosque, Madinah, KSA. The proposed mechanism in this paper is unique in two aspects.

A Novel Integration of Face-Recognition Algorithms with a Soft Voting Scheme for Efficiently Tracking Missing Person in Challenging Large-Gathering Scenarios.

The probability of losing vulnerable companions, such as children or older ones, in large gatherings is high, and their tracking is challenging. We proposed a novel integration of face-recognition algorithms with a soft voting scheme, which was applied, on low-resolution cropped images of detected faces, in order to locate missing persons in a challenging large-crowd gathering. We considered the large-crowd gathering scenarios at Al Nabvi mosque Madinah.

Incidence and Trends of Liver Cancer in the Gulf Cooperation Council States, 1998-2012.

Background: Liver cancer has been identified as the fifth most common cancer in males and ninth in females in the Gulf Cooperation Council (GCC) States. Taking into consideration that GCC states have comparable cultural and demographic backgrounds, this study aimed to examine the trends and patterns of liver cancer cases in the GCC states and to compare these with other regions.

Materials And Methods: The data were obtained from the Gulf Centre for Cancer Control and Prevention, which has maintained its database for GCC states since 1998.

Secure Health Monitoring Communication Systems Based on IoT and Cloud Computing for Medical Emergency Applications.

Smart health surveillance technology has attracted wide attention between patients and professionals or specialists to provide early detection of critical abnormal situations without the need to be in direct contact with the patient. This paper presents a secure smart monitoring portable multivital signal system based on Internet-of-Things (IoT) technology. The implemented system is designed to measure the key health parameters: heart rate (HR), blood oxygen saturation (SpO), and body temperature, simultaneously.

Identification of Gene Signature as Diagnostic and Prognostic Blood Biomarker for Early Hepatocellular Carcinoma Using Integrated Cross-Species Transcriptomic and Network Analyses.

Hepatocellular carcinoma (HCC) is considered the most common type of liver cancer and the fourth leading cause of cancer-related deaths in the world. Since the disease is usually diagnosed at advanced stages, it has poor prognosis. Therefore, reliable biomarkers are urgently needed for early diagnosis and prognostic assessment.

Forensic analysis of anti-forensic file-wiping tools on Windows.

This paper presents forensic analysis of anti-forensic file-wiping tools on the Windows platform. The goal is to identify and extract the evidence of the tools used to wipe files and the files wiped by them on the Windows operating system. To achieve this goal, we analyzed the changes made by these tools to metadata structures of Windows file systems during file wiping.

Forensic analysis of Twitch video streaming activities on Android.

Video streaming abuses range from copyright infringement and piracy to child sexual abuse and murder. This paper performs proactive forensics of Twitch video streaming activities on Android devices. We designed our experiments using a methodology based on black-box testing principles and conducted them on Android devices using a forensic framework.

Can computer forensic tools be trusted in digital investigations?

This paper investigates whether computer forensic tools (CFTs) can extract complete and credible digital evidence from digital crime scenes in the presence of file system anti-forensic (AF) attacks. The study uses a well-established six stage forensic tool testing methodology based on black-box testing principles to carry out experiments that evaluate four leading CFTs for their potential to combat eleven different file system AF attacks. Results suggest that only a few AF attacks are identified by all the evaluated CFTs, while as most of the attacks considered by the study go unnoticed.

Fibrolamellar hepatocellular carcinoma treated with atezolizumab and bevacizumab: two case reports.

Background: Fibrolamellar hepatocellular carcinoma is a unique tumor of the liver that differs from the classical hepatocellular carcinoma in diagnosis, behavior, and possibly treatment. There is usually absent underlying liver disease, and it usually occurs in young patients. The survival outcomes in localized fibrolamellar hepatocellular carcinoma are perhaps better than in classical hepatocellular carcinoma if treated early and radically.

Trends in Thyroid Cancer Incidence in the Gulf Cooperation Council States: a 15-Year Analysis.

Introduction: Thyroid cancer is a predominant malignancy in the Gulf Cooperation Council (GCC) states. Explicit regional assessments of incidence are crucial among countries that share similar demographic, cultural, and economic characteristics. This study provides an assessment of trends in thyroid cancer in the GCC over fifteen years.

Thyroid surgery in 103 children in a single institution from 2000-2014.

Background: Data on thyroid surgery in children are scarce.

Objective: Analyze outcome data on thyroid surgery in a pediatric population.

Design: Medical record review.

BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates.

Background: Papillary thyroid carcinoma (PTC) is the most common malignant thyroid neoplasm comprising 80-90% of all thyroid malignancies. Molecular changes in thyroid follicular cells are likely associated with the development of PTC. Mutations in serine/threonine-protein kinase (BRAF) and Rat sarcoma viral oncogene homolog (RAS) are commonly seen in PTC.

Spatial association between primary Middle East respiratory syndrome coronavirus infection and exposure to dromedary camels in Saudi Arabia.

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic disease. Exposure to dromedary camels (Camelus dromedaries) has been consistently considered the main source of primary human infection. Although Saudi Arabia reports the highest rate of human MERS-CoV infection and has one of the largest populations of dromedary camels worldwide, their spatial association has not yet been investigated.

Cervical Cancer Incidence and Trends among Nationals of the Gulf Cooperation Council States, 1998-2012.

Background: Cervical cancer is the ninth most common female malignancy in the Gulf Cooperation Council (GCC) States. We describe trends in cervical cancer incidence among GCC nationals. GCC states include Bahrain, Kuwait, Oman, Saudi Arabia, Qatar and the United Arab Emirates; which share similar demographic, socioeconomic and cultural backgrounds.

Spatiotemporal Clustering of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Incidence in Saudi Arabia, 2012-2019.

Middle East respiratory syndrome coronavirus (MERS-CoV) is a great public health concern globally. Although 83% of the globally confirmed cases have emerged in Saudi Arabia, the spatiotemporal clustering of MERS-CoV incidence has not been investigated. This study analysed the spatiotemporal patterns and clusters of laboratory-confirmed MERS-CoV cases reported in Saudi Arabia between June 2012 and March 2019.