Potential Application of Anti-Cyclic Citrullinated Peptide (Anti-CCP) for the Diagnosis of Periodontal Disease in Patients with Rheumatoid Arthritis with Cut-Off Determination.

Rheumatoid arthritis (RA) and periodontal disease (PD) are both characterized by an inflammatory reaction. Anti-cyclic citrullinated peptide (anti-CCP) is a common diagnostic test for RA. Anti-CCP is proposed to be used as a serological biomarker to detect PD in patients with RA.

Risk of Paradoxical Eczema in Patients Receiving Biologics for Psoriasis.

Importance: Biologics used for plaque psoriasis have been reported to be associated with an atopic dermatitis (AD) phenotype, or paradoxical eczema, in some patients. The risk factors for this are unknown.

Objective: To explore risk of paradoxical eczema by biologic class and identify factors associated with paradoxical eczema.

Integrated proteomics and genomics analysis of paradoxical eczema in psoriasis patients treated with biologics.

Background: Few studies have explored the immunology and genetic risk of paradoxical eczema occurring as an adverse event of biologic therapy in patients with psoriasis.

Objectives: We sought to describe the systemic inflammatory signature of paradoxical eczema using proteomics and explore whether this is genetically mediated.

Methods: This study used the Olink Target 96 Inflammation panel on 256 serum samples from 71 patients with psoriasis and paradoxical eczema, and 75 controls with psoriasis to identify differentially expressed proteins and enriched gene sets.

Correlation of Celiac Diseases with Candida Spp. Based on Anti-gliadin Antibodies.

A variety of Candida spp. can be found as a natural commensal fungus in various parts of the human body. This fungus may be associated with various diseases such as celiac disease (CD).

Parity in Correlation with Stage and Estrogen Receptor Type in Breast Cancer.

Background: Parity is related to breast cancer in various ways. Its effects on the development of breast cancer are not independent and should be investigated at the same time as other reproductive factors. The association between parity and stage and type of breast cancer receptor was studied.

Antimicrobial Activity of the Nanoparticle Form of Greens (Lemon, Black Seeds or Flax) with Silver on Drug-resistant Human Pathogens.

Background: Synthesizing a green source that has antimicrobial activity in nanoparticles is a novel and exciting approach to pharmaceutical science with promising results.

Objective: Green-silver nanoparticles (G-AgNPs) were evaluated for their antimicrobial action on drugresistant pathogens.

Methods: Lemon, black seeds, and flax were selected as green sources to synthesize nanoparticles formed with silver.

A Positive or Negative Connection of Diabetes Mellitus to the Oral Microbiota.

Common noncommunicable diabetes mellitus disease has many complications in several parts of the human body. The oral cavity is one of the areas affected by diabetes mellitus conditions. The most common complications of diabetes mellitus in oral areas include increased drying of the mouth and increased oral diseases resulting from either microbial activity, such as dental caries, periodontal diseases, and oral candidiasis, or physiological problems, such as oral cancer, burning mouth syndrome, and temporomandibular disorders.

Atopic Polygenic Risk Score Is Associated with Paradoxical Eczema Developing in Patients with Psoriasis Treated with Biologics.

Biologic therapies for psoriasis can cause paradoxical eczema. The role of genetic factors in its pathogenesis is unknown. To identify risk variants, we conducted a GWAS of 3,212 patients with psoriasis, of whom 88 developed paradoxical eczema.

The effect of immunomodulators on seroconversion after BNT162b2 and AZD1222 vaccines in patients with immune-mediated inflammatory diseases: a prospective cohort study.

Background: Biologic and nonbiologic immunomodulators, used to treat immune-mediated inflammatory diseases (IMIDs), could impair the immune response to COVID-19 vaccines and thus vaccine effectiveness.

Objectives: Our objective was to investigate the association between biologic and nonbiologic immunomodulators and seroconversion following the first and second dose of COVID-19 vaccines in patients with IMIDs.

Methods: Serum samples were collected following the first or second dose of the BNT162b2 or AZD1222 vaccines from patients receiving biologic and/or nonbiologic immunomodulators for one or more of psoriasis, psoriatic arthritis, rheumatoid arthritis, inflammatory bowel disease or systemic lupus erythematosus.

Global Guidelines in Dermatology Mapping Project (GUIDEMAP): a systematic review of alopecia areata clinical practice guidelines.

Introduction: Alopecia areata (AA) is a nonscarring alopecia with an estimated global prevalence of 2% and limited data on the efficacy of current treatment. Clinical practice guidelines (CPGs) provide recommendations based on best available evidence. It is unclear how many AA CPGs are available globally.

The influence of age, menstrual state and body mass index on the relation between osteopenia and osteoporosis associated with breast cancer.

Osteoporosis and body mass index (BMI) have been reported to be associated with breast cancer. The correlation between other types of bone loss and breast cancer requires further illustrative evidence. Effect of age and menstrual state on the relationship of osteoporosis, osteopenia and BMI with breast cancer was evaluated in this study.

Paradoxical eczema in patients with psoriasis receiving biologics: a case series.

Atopic eczema and psoriasis are chronic, inflammatory dermatoses that can significantly affect the quality of life of those affected. Although both diseases are common, they rarely occur together. Severe psoriasis can be treated with biologic therapies targeting specific cytokine pathways involved in disease pathogenesis.

Early diagnosis of aspergillosis in asthmatic and rheumatoid arthritis patients by galactomannan antigen assay: a case-control study in Karbala providence.

Objective: Aspergillosis is an opportunistic systemic infection caused by members of spp. in various parts of the human body. Chronic diseases such as rheumatoid arthritis (RA) and asthma may encourage the development of aspergillosis under specific conditions.

Prophylaxis and Therapeutic Ability of Inactivated Dermatophytic Vaccine Against Dermatophytosis in the Rabbits as an Animal Model.

Objectives: Dermatophytosis is a group of cutaneous diseases widely distributed in human and animals. It causes serious infection in some human cases and economic losses in farm animals. The primary aim of this study is to conduct an investigation of prophylaxis and a potential therapeutic vaccine against dermatophytosis.

Repurposing of Tamoxifen Against the Oral Bacteria.

Objectives: Tamoxifen (TAM), which is used for treating breast cancer, has exhibited another important function as an antimicrobial agent. The objective of this study is to investigate the antibacterial action of TAM against the bacteria present in the human oral cavity.

Materials And Methods: The bacteria present in the human oral cavity were isolated from healthy individuals.

Real-World Experience and Laboratory Monitoring of Dupilumab in Patients with Moderate to Severe Atopic Dermatitis in a Tertiary Centre.

Introduction: Dupilumab is a biologic therapy approved for treatment of moderate to severe atopic dermatitis (AD). Our objective was to assess the real-world effectiveness, safety and laboratory monitoring practices for dupilumab in a tertiary centre.

Methods: A retrospective review of medical records of all patients receiving dupilumab between September 2017 and October 2019 was undertaken.

Seborrhoeic dermatitis and sebopsoriasis developing in patients on dupilumab: Two case reports.

Cutaneous adverse events to dupilumab can be varied; this necessitates keeping a broad differential diagnosis to identify seemingly paradoxical reactions. It may be possible to treat the adverse event concurrently without stopping dupilumab.

Development of a new synthetic xerogel nanoparticles of silver and zinc oxide against causative agents of dermatophytoses.

Background: Dermatophytes, which are the common causative agents of superficial infection on the human skin called dermatophytosis that can be treated by various antifungal drugs. Nanoparticles composed of such drugs have many benefits. A new form called xerogel of silver nanoparticles (Ag-NPs) and zinc oxide nanoparticles (ZnO-NPs) was prepared and tested against dermatophytes.

Interfering Effect of Black Tea Consumption on Diagnosis of Pancreatic Cancer by CA 19-9.

Purpose: The study aims to determine the possible effects of black tea consumption on the level of CA 19-9 antigen in the human body.

Methods: The level of CA 19-9 was measured in 270 healthy individuals who consumed heavy amounts of black tea.

Results: About 43.

Suitability of hair type for dermatophytes perforation and differential diagnosis of T. mentagrophytes from T. verrucosum.

Most of the dermatophyte species have the ability to perforate hair structure and consume its contents of keratin through secretion of keratinase enzyme. Two clinical isolated species of dermatophytes were diagnosed as Trichophyton mentagrophytes var. granulosum and Trichophyton verrucosum.

Pemphigus vulgaris: a rare cause of dysphagia.

Pemphigus vulgaris is a rare autoimmune blistering disease of the skin and mucous membranes. The case reported presented unusually with dyspepsia that was not responsive to protein pump inhibitor (PPI) therapy. This progressed to severe dysphagia and odynophagia.

Potential activity of the purine compounds caffeine and aminophylline on bacteria.

Background: Purine compounds are special types of alkaloids. Caffeine and aminophylline are considered the most important members of purines due to their wide use in therapeutics.

Aims: To detect any potential antibacterial effects on pathogenic bacteria of the widely prescribed members of purines caffeine and aminophylline.

Determination of antidermatophytic effects of non-steroidal anti-inflammatory drugs on Trichophyton mentagrophytes and Epidermophyton floccosum.

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most common pharmacological agents. They have three primary therapeutic properties including anti-inflammatory, anti-pyretic and analgesic effects. Seven NSAIDs were tested against two species of dermatophytes.

Elevation of antidermatophytic action of mefenamic acid by cobalt ions.

Objectives: To evaluate the antifungal property of mefenamic acid, which is a member of non-steroidal anti-inflammatory drugs (NSAIDs) group.

Materials And Methods: In order to evaluate the antifungal property of mefenamic acid on dermatophytes, it was mixed with cobalt (Co) in culture media. Two species related to two genera of dermatophytes were tested for their susceptibility to mefenamic acid and its complex with Co by using colony diameter measurement method.