Potassium bromate-induced oxidative stress, genotoxicity and cytotoxicity in the blood and liver cells of mice.

Potassium bromate (KBrO) is an oxidising agent that is extensively used as a food additive, it is also a product of cosmetic and pharmaceutical relevance. The objective of this study was to evaluate the oxidative stress, genotoxicity, and apoptosis induced by KBrO in an experimental animal model. To study the toxic effects and oxidative stress, different doses of KBrO below LD (The half maximal lethal dose, 50, 100 and 150 mg/kg body weight) were given intraperitoneally to the mice for multiple time periods (24, 48, and 72 h).

Protective Effect of Extract against Potassium Bromate Induced Oxidative Stress and Genotoxicity in Mice.

Despite the commercial value of potassium bromate (KBrO), it has been linked to many diseases including cancer. possesses exceptional ethnobotanical, pharmaceutical, and economic prominence by virtue of its bioactive components. The present study was designed to explore the protective role and antioxidant potential of ethanolic leaves extract of against the oxidative stress, genotoxicity, and apoptosis induced by KBrO in an experimental animal model.