Effects of Antimicrobial Flavonoids Against Representative Bacteria and Fungi: A Review of the Literature.

Introduction:  Effective medications are becoming more necessary to combat the global rise in antimicrobial resistance. The findings that some flavonoids have antibacterial properties have urged interest in flavonoid research. The aim of this work was to investigate the inhibitory properties of fisetin, fisetinidin, 7,3`,4`-trihydroxyflavone (THF), and 7,3`,4`-trihydroxyflavonol (THF-) against selected pathogenic bacteria and fungi and to review the literature on relevant compounds.

Global environmental and toxicological impacts of polybrominated diphenyl ethers versus organophosphate esters: A comparative analysis and regrettable substitution dilemma.

The prevalence of organophosphate esters (OPEs) in the global environment is increasing, which aligns with the decline in the usage of polybrominated diphenyl ethers (PBDEs). PBDEs, a category of flame retardants, were banned and classified as persistent organic pollutants (POPs) through the Stockholm Convention due to their toxic and persistent properties. Despite a lack of comprehensive understanding of their ecological and health consequences, OPEs were adopted as replacements for PBDEs.

Repurposing of approved drugs for targeting CDK4/6 and aromatase protein using molecular docking and molecular dynamics studies.

Breast cancer is a leading cause of cancer-related morbidity and mortality worldwide, with the highest incidence among women. Among the various subtypes of breast cancer, estrogen-receptor positive (ER+) is the most diagnosed. Estrogen upregulates cyclin D1, which in turn promotes the activity of CDK4/6 and facilitates cell cycle progression.