Influence of variation in indium concentration and temperature on the threshold current density in In Ga As/GaAs QD laser diodes.

The influence of variations in indium concentration and temperature on threshold current density (J) in In Ga As/GaAs ( = 0, 0.8 and 0.16) quantum dot (QD) laser diodes - synthesized via molecular beam epitaxy (MBE) with three distinct indium concentrations on GaAs (001) substrates - was meticulously examined.

Physiological effects of hand grip and cold pressor tests in young Saudi adults.

The risk of cardiovascular disease differs among various ethnic groups, highlighting disparities in cardiovascular health among different populations. While multiple studies from other countries have looked at changes in physiological parameters during autonomic function tests like isometric handgrip and cold pressor tests, no correlational research has been done in Saudi Arabia. This lacuna underscores the importance of examining the relationship between cardiorespiratory parameters in young Saudi Arabian individuals during these tests.

Identifying subgroups of teacher burnout in elementary and secondary schools: the effects of teacher experience, age and gender.

Introduction: Teacher burnout is a serious problem that requires quick attention and management since it not only compromises educational quality but also strains schools' financial resources.

Research Objective: The purpose of the present study was to profile burnout indicators for teachers in the Kingdom of Saudi Arabia. A secondary goal was to evaluate the consistency of burnout profiles between elementary and secondary school teachers.

Developing and validating a scale to measure perceived barriers to prosthodontics treatments among partially edentulous patients.

Background: People experiencing tooth loss need dental prostheses to preserve the integrity of their oral structures and replace the missing teeth. Patient-related outcome measures (PROMs) for perceived barriers to prosthodontics treatment are scarce in the literature.

Aims: The aim of this study was to develop a comprehensive scale to identify and measure barriers to prosthodontic treatment as perceived by partially edentulous patients.

Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis.

Multiple sclerosis (MS) affects 2.8 million people worldwide. Although the cause is unknown, various risk factors might be involved.

Enhanced Photoelectrocatalytic Performance of ZnO Nanowires for Green Hydrogen Production and Organic Pollutant Degradation.

With growing environmental concerns and the need for sustainable energy, multifunctional materials that can simultaneously address water treatment and clean energy production are in high demand. In this study, we developed a cost-effective method to synthesize zinc oxide (ZnO) nanowires via the anodic oxidation of zinc foil. By carefully controlling the anodization time, we optimized the Zn/ZnO-5 min electrode to achieve impressive dual-function performance in terms of effective photoelectrocatalysis for water splitting and waste water treatment.

Genomic Insights into Blood Pressure Regulation: Exploring Ion Channel and Transporter Gene Variations in Jordanian Hypertensive Individuals.

: Hypertension (HTN) constitutes a significant global health burden, yet the specific genetic variant responsible for blood pressure regulation remains elusive. This study investigates the genetic basis of hypertension in the Jordanian population, focusing on gene variants related to ion channels and transporters, including , , , , , , , , and . : This research involved 200 hypertensive patients and 224 healthy controls.

Betalain-Chickpea Protein Particles Produced by Freeze Drying and Spray Drying: Physicochemical Aspects, Storage Stability, and In Vitro Digestion.

Beetroots are one of the primary sources of betalains, nitrogenous pigments with anti-inflammatory and antioxidant properties. However, due to their chemical instability, betalains have limited use in food applications. This work investigated whether betalains encapsulated in chickpea protein could be stabilized and delivered in a shelf-stable format.

Estimation and Characterization of Dengue Serotypes in Patients Presenting with Dengue Fever at Makkah Hospitals.

Dengue fever is caused by four common serotypes of the dengue virus (DENV-1, DENV-2, DENV-3, and DENV-4). Patients infected with one serotype may develop lifelong serotype-specific protective immunity. However, they remain susceptible to reinfection with the other serotypes, often increasing the risk of severe forms of dengue.

Association Between Oral Health Complaints and Nutritional Status among Patients with Cancer: A Study Utilising the Mini Nutritional Assessment Short Form.

Purpose: Oral health problems in patients with cancer can substantially affect their quality of life, treatment outcomes, and overall nutritional well-being. This study investigated the relationship between nutritional status and self-reported oral health complaints in patients with cancer.

Materials And Methods: A cross-sectional study was conducted among patients with cancer at the King Saud University Medical City Oncology Center in Riyadh, Saudi Arabia.

Prospective Applications of Artificial Intelligence In Fetal Medicine: A Scoping Review of Recent Updates.

Introduction: With the incorporation of artificial intelligence (AI), significant advancements have occurred in the field of fetal medicine, holding the potential to transform prenatal care and diagnostics, promising to revolutionize prenatal care and diagnostics. This scoping review aims to explore the recent updates in the prospective application of AI in fetal medicine, evaluating its current uses, potential benefits, and limitations.

Methods: Compiling literature concerning the utilization of AI in fetal medicine does not appear to modify the subject or provide an exhaustive exploration of electronic databases.

Exploring the Association Between Hypothyroidism, Mean Platelet Volume, and Red Cell Distribution Width: A Case-Control Study.

Background: Thyroid hormones are important in regulating hematopoiesis. Recent research has suggested that red cell distribution width (RDW) and mean platelet volume (MPV) may be useful inflammatory markers in various disorders, including thyroid disorders. Hence, the study aimed to evaluate the association between hypothyroidism, RDW, and MPV.

Non-coding RNAs in urinary bladder cancer microenvironment: Diagnostic, therapeutic, and prognostic perspective.

Urinary bladder cancer (UBC) is the ninth most common cancer worldwide. Despite the reliance of UBC therapy on definite pathological grading and classifications, the clinical response among patients varies widely. The molecular basis of this type of cancer appeals to considerable research; hence, new diagnostic and therapeutic options are introduced.

Non-Invasive Cancer Detection Using Blood Test and Predictive Modeling Approach.

Purpose: The incidence of cancer, which is a serious public health concern, is increasing. A predictive analysis driven by machine learning was integrated with haematology parameters to create a method for the simultaneous diagnosis of several malignancies at different stages.

Patients And Methods: We analysed a newly collected dataset from various hospitals in Jordan comprising 19,537 laboratory reports (6,280 cancer and 13,257 noncancer cases).

Improving Imitation Skills in Children with Autism Spectrum Disorder Using the NAO Robot and a Human Action Recognition.

Autism spectrum disorder (ASD) is a group of developmental disorders characterized by poor social skills, low motivation in activities, and a lack of interaction with others. Traditional intervention approaches typically require support under the direct supervision of well-trained professionals. However, teaching and training programs for children with ASD can also be enhanced by assistive technologies, artificial intelligence, and robotics.

Primary intrarenal hemangioma - A series of 39 cases.

Intrarenal hemangiomas lack concise clinicopathologic information, due to the predominance of single case reports and inclusion of other vascular neoplasms and hemangiomas of perirenal, hilar, and renal vein origin. Herein, in this multi-institutional study we evaluate clinicopathologic features of 39 intrarenal hemangiomas. The median age was 62 years (range = 27-94 years; 2:1 male to female ratio), with left-sided predominance (left = 21, right = 13; one case was bilateral).

Graft ischemia post cell transplantation to the brain: Glucose deprivation as the primary driver of rapid cell death.

Replacing cells lost during the progression of neurodegenerative disorders holds potential as a therapeutic strategy. Unfortunately, the majority of cells die post-transplantation, which creates logistical and biological challenges for cell therapy approaches. The cause of cell death is likely to be multifactorial in nature but has previously been correlated with hypoxia in the graft core.

Origin and branching pattern of the iliohypogastric and ilioinguinal nerves and their exits in relation to the psoas major muscle: a cadaveric study.

This study aims to determine the level of origin, branching pattern and exits of the iliohypogastric and ilioinguinal nerves in relation to the psoas major muscle. Additionally, this study confirms the presence and retroperitoneal courses of the double nerves. We dissected a total of 24 iliohypogastric and ilioinguinal nerves (6 male and 6 female cadavers).

Prevalence of self-reported asthma in type 1 diabetes children and its associated predictors.

Background: Asthma is considered one of the most common and serious noncommunicable diseases, with high morbidity and mortality rates in both children and adults.

Objectives: To estimate the frequency and to determine the associated factors of self-reported asthma among children diagnosed with type 1 diabetes.

Methods: A cross-sectional study design was employed, and 175 subjects having type 1 diabetes for more than 1 year were included from the pediatrics endocrine clinic.

Dual Targeting of MEK1 and Akt Kinase Identified SBL-027 as a Promising Lead Candidate to Control Cell Proliferations in Gastric Cancer.

Dual inhibition of Akt and MEK1 pathways offers a promising strategy to enhance treatment efficacy in gastric cancer. In this study, we employed computational approaches followed by in vitro validations. Our results demonstrate that SBL-027 exhibits robust and enduring interactions with Akt and MEK1 kinases, as evidenced by atomistic molecular dynamics simulations and molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) based binding free energy estimates.

Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement.

This study aimed to investigate the potential of Pichia kudriavzevii (PK), a newly discovered yeast strain, in alleviating the deleterious effects induced by aflatoxins on broilers. Eighty one-day-old broiler chicks were divided into four groups and subjected to various combinations of aflatoxin dosages at 300 μg/kg of feed alongside PK supplementation at 1 g/kg of feed. Assessment encompassed a comprehensive array of parameters including performance metrics, hepatic and renal biomarkers, interleukin concentrations, blood cell counts, hemoglobin concentration, packed cell volume, antibody response to sheep red blood cells, lymphoproliferative response to PHA-P, phagocytic response utilizing the carbon clearance assay system, as well as evaluation of oxidants and antioxidants.

Awareness of Obesity and Weight Loss Management Among Adults in the Asir Region, Saudi Arabia.

Obesity, a chronic disease marked by excessive fat accumulation and a body mass index (BMI) of 30 kg/m² or more, has become a major global health issue, affecting many adults worldwide and particularly prevalent in developed nations and Saudi Arabia. The condition can be caused by genetic, metabolic, and lifestyle factors. Understanding its awareness is imperative in designing effective health interventions.

Real-world clinical outcome of unresectable locally advanced & de-novo metastatic pancreatic ductal adenocarcinoma: a multicentre retrospective study.

Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited treatment options yielding poor outcomes. This study aimed to evaluate the real-world clinical characteristics, treatment patterns, and outcomes of patients with locally advanced unresectable and de-novo metastatic PDAC in Saudi Arabia, providing regional data to compare with international benchmarks.

Methods: This is a retrospective, multicentre study involving 350 patients diagnosed with unresectable locally advanced or de-novo metastatic PDAC between January 2015 and November 2023.

CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans.

Four genes-DAND5, PKD1L1, MMP21, and CIROP-form a genetic module that has specifically evolved in vertebrate species that harbor motile cilia in their left-right organizer (LRO). We find here that CIROZ (previously known as C1orf127) is also specifically expressed in the LRO of mice, frogs, and fish, where it encodes a protein with a signal peptide followed by 3 zona pellucida N domains, consistent with extracellular localization. We report 16 individuals from 10 families with bi-allelic CIROZ inactivation variants, which cause heterotaxy with congenital heart defects.