Publications by authors named "Alfredo Smart"
In animals, microRNA (miRNA) biogenesis begins with cotranscriptional cleavage of the primary (pri-)miRNA by the Microprocessor complex. Cotranscriptional splicing has been shown to influence Microprocessor cleavage when miRNAs are hosted in introns of protein-coding pri-miRNAs, but the impact of splicing on production of miRNAs hosted in long non-coding (lnc)RNAs is largely unknown. Here, we investigated the role of splicing in the biogenesis of miR-122, an lncRNA-hosted, highly expressed, medically important, liver-specific miRNA.
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- Pfam has seen substantial growth, now featuring 17,929 families in release 32.0, with ongoing efforts to enhance existing families through improved domain boundaries and functional annotations.
- Collaboration with RepeatsDB has led to better definitions for tandem repeat families, while a comparison with the ECOD database resulted in the creation of 825 new family classifications.
- The integration of authors' ORCID identifiers allows contributors to receive appropriate credit for their work in Pfam, linking their contributions to their academic profiles.