Publications by authors named "Alfredo Iglesias-Cadarso"
The resolution of inflammation is a complex process that is critical for removing inflammatory cells and restoring tissue function. The dysregulation of these mechanisms leads to chronic inflammatory disorders. Platelets, essential cells for preserving homeostasis, are thought to play a role in inflammation as they are a source of immunomodulatory factors.
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- Scientists are trying to understand why some people with severe allergies have ongoing inflammation in their bodies, but it’s still a mystery.
- They studied T cells (a type of immune cell) from allergic asthma patients and found that those with severe allergies showed different behaviors and changes in their genes compared to mild patients and healthy people.
- The severe allergic patients had fewer working genes related to energy production, but more genes that cause inflammation, suggesting their immune system isn't regulating itself properly.
Background: Mechanisms causing the onset and perpetuation of inflammation in severe allergic patients remain unknown. Our previous studies suggested that severe allergic inflammation is linked to platelet dysfunction.
Methods: Platelet-rich plasma (PRP) and platelet-poor plasma (PPP) samples were obtained by platelet-apheresis from severe (n = 7) and mild (n = 10) allergic patients and nonallergic subjects (n = 9) to perform platelet lipidomics by liquid chromatography coupled to mass spectrometry (LC-MS) and RNA-seq analysis.
Risk factors for systemic reactions to allergen immunotherapy.
Curr Opin Allergy Clin Immunol
December 2011
Purpose Of Review: To update safety information regarding allergen-specific immunotherapy (ASIT) in clinical practice and highlight the risk factors associated with the adverse reactions, product and each dose.
Recent Findings: Efforts in recent years have focused on increasing our understanding of the efficacy and safety of ASIT, especially the sublingual variety (SLIT), in multicenter studies. Moreover, new Clinical Practice Guidelines (CPGs) and an international consensus concerning ASIT have been published recently.
Background And Objective: The purpose of this study was to describe the clinical and epidemiological features of anaphylactic reactions to hymenoptera stings, with a case-history analysis according to severity.
Patients And Method: We conducted an observational descriptive study of patients aged between 10 and 80 years who suffered a systemic reaction after hymenoptera sting. All of them showed specific serum IgE to venoms from Apis, Vespula and/or Polistes.