Publications by authors named "Alfredo Fernandez-Rodriguez"
Radiother Oncol
December 2024
Article Synopsis
- Proton Minibeam Radiation Therapy (pMBRT) is a unique technique that modulates radiation dose delivery to potentially enhance anti-tumor immune responses while impacting treatment outcomes through specific dosimetric parameters like peak and valley doses.*
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- The study used an orthotopic rat model of glioblastoma to explore how different pMBRT configurations influence survival and immune response, finding that higher dose heterogeneity and maintaining a minimum valley dose improved overall outcomes.*
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- Results indicated that optimizing both peak doses and valley doses led to better tumor eradication and less immunosuppression, contrasting with traditional proton therapy that usually creates uniform dose distributions.*
