Connecting genomic and proteomic signatures of amyloid burden in the brain.

Background: Alzheimer's disease (AD) has a high heritable component characteristic of complex diseases, yet many of the genetic risk factors remain unknown. We combined genome-wide association studies (GWAS) on amyloid endophenotypes measured in cerebrospinal fluid (CSF) and positron emission tomography (PET) as surrogates of amyloid pathology, which may be helpful to understand the underlying biology of the disease.

Methods: We performed a meta-analysis of GWAS of CSF Aβ42 and PET measures combining six independent cohorts (n=2,076).

A Case Series and Literature Review of Subacute Infective Endocarditis: A Clinical Challenge.

Endocarditis is a life-threatening, relatively rare disease caused by an infection of the endocardial epithelium of the heart. Its clinical presentation is highly variable, depending on whether it presents acutely, subacutely, or chronically. Also, the wide array of causal etiologies and pathogens makes its diagnosis and treatment complex and challenging.

Recommendations for coastal planning and beach management in Caribbean insular states during and after the COVID-19 pandemic.

The COVID-19 pandemic has implications for coastal planning and management. Rules for isolation and physical distancing, among other measures for human life protection, have led to the closure of most beaches around the world. The present critical situation has raised the following question: How can some recommendations be designed in sun, sea, and sand tourism-dependent-insular countries to face "the COVID-19 new normality?" We used the content analysis technique to analyze representative publications on a global level to ascertain information on best management practices.

Laparoscopic Roux-en-Y gastric bypass as a revision procedure after restrictive bariatric surgery.

Background: Adjustable gastric banding (AGB) and vertical banded gastroplasty (VBG) have been extensively used to treat morbid obesity. Patients with insufficient weight loss or complications may require surgical revision. The laparoscopic Roux-en-Y gastric bypass (LRYGBP) is one of the most common procedures currently used for revision.