Publications by authors named "Alfredo Alaniz-Palacios"
Article Synopsis
- Calcium-activated chloride channels (CaCCs), particularly TMEM16A and TMEM16B proteins, are crucial for various physiological processes and their dysfunction is linked to diseases like cancer, asthma, and hypertension.
- Inhibition of CaCCs in recent studies shows potential for treating some illnesses, but there are limited specific modulators available.
- The study identifies that GSK2193874 boosts chloride currents in TMEM16B and that GSK1016790A enhances native CaCCs, presenting these compounds as useful tools to further explore CaCCs and TRPV4 channels and their interactions.
GABAergic and dopaminergic pathways are co-localized in several areas of the central nervous system and recently several reports have shown co-release of both neurotransmitters. The GABA-A receptor (β and ρ1 subunits) is modulated by dopamine (DA) and, interestingly, GABAρ1 can be modulated by several biogenic amines. Here we explored the effects of the metabolites of the dopaminergic pathway and other structural analogues of DA on GABAρ1 and the DA gated ion channel (LGC-53) from Caenorhabditis elegans expressed in Xenopus laevis oocytes.
View Article and Find Full Text PDFA tetrazole isosteric analogue of clofibric acid (1) was prepared using a short synthetic route and was characterized by elemental analysis, NMR ((1)H, (13)C) spectroscopy, and single-crystal X-ray diffraction. The in vitro inhibitory activity of 1 against 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) was evaluated, showing a moderate inhibitory enzyme activity (51.17% of inhibition at 10 μM), being more active than clofibrate and clofibric acid.
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