Publications by authors named "Alfred Mertins"

Human sleep is cyclical with a period of approximately 90 minutes, implying long temporal dependency in the sleep data. Yet, exploring this long-term dependency when developing sleep staging models has remained untouched. In this work, we show that while encoding the logic of a whole sleep cycle is crucial to improve sleep staging performance, the sequential modelling approach in existing state-of-the-art deep learning models are inefficient for that purpose.

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Background: Despite the tremendous prog- ress recently made towards automatic sleep staging in adults, it is currently unknown if the most advanced algorithms generalize to the pediatric population, which displays distinctive characteristics in overnight polysomnography (PSG).

Methods: To answer the question, in this work, we conduct a large-scale comparative study on the state-of-the-art deep learning methods for pediatric automatic sleep staging. Six different deep neural networks with diverging features are adopted to evaluate a sample of more than 1,200 children across a wide spectrum of obstructive sleep apnea (OSA) severity.

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Background: Black-box skepticism is one of the main hindrances impeding deep-learning-based automatic sleep scoring from being used in clinical environments.

Methods: Towards interpretability, this work proposes a sequence-to-sequence sleep-staging model, namely SleepTransformer. It is based on the transformer backbone and offers interpretability of the model's decisions at both the epoch and sequence level.

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Magnetic Particle Imaging is a tomographic imaging technique that measures the voltage induced due to magnetization changes of magnetic nanoparticle distributions. The relationship between the received signal and the distribution of the nanoparticels is described by the system function. A common method for image reconstruction is using a measured system function to create a system matrix and set up a regularized linear system of equations.

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This work takes a step towards a better biosignal based hand gesture recognition by investigating the strategies for a reliable prediction of hand joint angles. Those strategies are especially important for medical applications in order to achieve e.g.

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This paper presents an inception-based deep neural network for detecting lung diseases using respiratory sound input. Recordings of respiratory sound collected from patients are first transformed into spectrograms where both spectral and temporal information are well represented, in a process referred to as front-end feature extraction. These spectrograms are then fed into the proposed network, in a process referred to as back-end classification, for detecting whether patients suffer from lung-related diseases.

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Purpose: To improve the robustness of diffusion-weighted imaging (DWI) data acquired with segmented simultaneous multi-slice (SMS) echo-planar imaging (EPI) against in-plane and through-plane rigid motion.

Theory And Methods: The proposed algorithm incorporates a 3D rigid motion correction and wavelet denoising into the image reconstruction of segmented SMS-EPI diffusion data. Low-resolution navigators are used to estimate shot-specific diffusion phase corruptions and 3D rigid motion parameters through SMS-to-volume registration.

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Automating sleep staging is vital to scale up sleep assessment and diagnosis to serve millions experiencing sleep deprivation and disorders and enable longitudinal sleep monitoring in home environments. Learning from raw polysomnography signals and their derived time-frequency image representations has been prevalent. However, learning from multi-view inputs (e.

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This paper presents and explores a robust deep learning framework for auscultation analysis. This aims to classify anomalies in respiratory cycles and detect diseases, from respiratory sound recordings. The framework begins with front-end feature extraction that transforms input sound into a spectrogram representation.

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Most wearable human-machine interfaces concerning hand movements only focus on classifying a limited number of hand gestures. With the introduction of deep learning, surface electromyography based hand gesture classification systems improved drastically. Therefore, it is worth investigating whether the classification can be replaced by a movement regression of all the different movable hand parts.

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Background: Despite recent significant progress in the development of automatic sleep staging methods, building a good model still remains a big challenge for sleep studies with a small cohort due to the data-variability and data-inefficiency issues. This work presents a deep transfer learning approach to overcome these issues and enable transferring knowledge from a large dataset to a small cohort for automatic sleep staging.

Methods: We start from a generic end-to-end deep learning framework for sequence-to-sequence sleep staging and derive two networks as the means for transfer learning.

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The hypothalamus and insular cortex play an essential role in the integration of endocrine and homeostatic signals and their impact on food intake. Resting-state functional connectivity alterations of the hypothalamus, posterior insula (PINS) and anterior insula (AINS) are modulated by metabolic states and caloric intake. Nevertheless, a deeper understanding of how these factors affect the strength of connectivity between hypothalamus, PINS and AINS is missing.

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Objective: Brain waves vary between people. This work aims to improve automatic sleep staging for longitudinal sleep monitoring via personalization of algorithms based on individual characteristics extracted from sleep data recorded during the first night.

Approach: As data from a single night are very small, thereby making model training difficult, we propose a Kullback-Leibler (KL) divergence regularized transfer learning approach to address this problem.

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For many applications, hand gesture recognition systems that rely on biosignal data exclusively are mandatory. Usually, theses systems have to be affordable, reliable as well as mobile. The hand is moved due to muscle contractions that cause motions of the forearm skin.

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Sleep staging, a process of identifying the sleep stages associated with polysomnography (PSG) epochs, plays an important role in sleep monitoring and diagnosing sleep disorders. We present in this work a model fusion approach to automate this task. The fusion model is composed of two base sleep-stage classifiers, SeqSleepNet and DeepSleepNet, both of which are state-of-the-art end-to-end deep learning models complying to the sequence-to-sequence sleep staging scheme.

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Multi-shot techniques offer improved resolution and signal-to-noise ratio for diffusion- weighted imaging, but make the acquisition vulnerable to shot-specific phase variations and inter-shot macroscopic motion. Several model-based reconstruction approaches with iterative phase correction have been proposed, but robust macroscopic motion estimation is still challenging. Segmented diffusion imaging with iterative motion-corrected reconstruction (SEDIMENT) uses iteratively refined data-driven shot navigators based on sensitivity encoding to cure phase and rigid in-plane motion artifacts.

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Purpose: Magnetic particle imaging is a tomographic imaging technique that allows one to measure the spatial distribution of superparamagnetic nanoparticles, which are used as tracer. The magnetic particle imaging scanner measures the voltage induced due to the nonlinear magnetization behavior of the nanoparticles. The tracer distribution can be reconstructed from the voltage signal by solving an inverse problem.

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Objective: Resting-state functional magnetic resonance imaging (rs-fMRI) has become an essential measure to investigate the human brain's spontaneous activity and intrinsic functional connectivity. Several studies including our own previous work have shown that the brain controls the regulation of energy expenditure and food intake behavior. Accordingly, we expected different metabolic states to influence connectivity and activity patterns in neuronal networks.

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To study the interplay of metabolic state (hungry vs. satiated) and glucose administration (including hormonal modulation) on brain function, resting-state functional magnetic resonance imaging (rs-fMRI) and blood samples were obtained in 24 healthy normal-weight men in a repeated measurement design. Participants were measured twice: once after a 36 h fast (except water) and once under satiation (three meals/day for 36 h).

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This work focuses on a system for hand prostheses that can overcome the delay problem introduced by classical approaches while being reliable. The proposed approach based on a recurrent neural network enables us to incorporate the sequential nature of the surface electromyogram data and the proposed system can be used either for classification or early prediction of hand movements. Especially the latter is a key to a latency free steering of a prosthesis.

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One objective way to evaluate the effect of noise reduction algorithms in hearing aids is to measure the increase in signal-to-noise-ratio (SNR). To this end, Hagerman and Olofsson presented a method where multiple recordings take place and the phase of one signal is inverted between the measurements. This phase inversion method allows one to separate signal and noise at the output of the hearing aid so that the increase in SNR can be evaluated.

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A major regulatory task of the organism is to keep brain functions relatively constant in spite of metabolic changes (e.g., hunger vs.

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We study in this work the feasibility of early prediction of hand movement based on sEMG signals to overcome the time delay issue of the conventional classification. Opposed to the classification task, the objective of early prediction is to predict a hand movement that is going to occur in the future given the information up to the current time point. The ability of early prediction may allow a hand prosthesis control system to compensate for the time delay and, as a result, improve the usability.

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Closed-room scenarios are characterized by reverberation, which decreases the performance of applications such as hands-free teleconferencing and multichannel sound reproduction. However, exact knowledge of the sound field inside a volume of interest enables the compensation of room effects and allows for a performance improvement within a wide range of applications. The sampling of sound fields involves the measurement of spatially dependent room impulse responses, where the Nyquist-Shannon sampling theorem applies in the temporal and spatial domains.

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In this paper, we discuss an event detection system using a wireless sensor network in the Ambient Assisted Living context. The sensors measure the environment in which the patients live, not vital parameters of the patient him- or herself, which is important in order to respect the privacy and informational self-determination of the patient. The major difficulties of the given setup with sensors in the environment are that the measurements are taken in an irregular fashion (as opposed to regular sampling) and that some of the sensors may be unreliable.

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