Publications by authors named "Alfred Chi Chung Leung"
Article Synopsis
- DEC1, a potential tumor suppressor gene, is significantly downregulated in esophageal carcinoma, with absence in all tested ESCC cell lines and a majority of tumor samples from high-risk regions in China.
- In experiments, DEC1 expression led to smaller cell colonies but did not notably increase colony numbers in 3D cultures, suggesting its role in limiting colony growth rather than preventing cell proliferation.
- Further analysis identified three candidate genes (TFPI-2, GDF15, DUSP6) impacted by DEC1 that are also downregulated in tumors, indicating their possible involvement in tumor growth and progression in esophageal cancer.
The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated. Reduced expression of BLU was detected in some ESCC cell lines and tumor tissues and the difference was quantitated by real-time quantitative polymerase chain reaction.
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