Publications by authors named "Alfonso Monereo"
Article Synopsis
- - Plitidepsin, a cyclic-peptide from marine sources, effectively inhibits SARS-CoV-2 replication by targeting an important host protein, showing its strongest effects in lung tissue compared to blood.
- - A clinical study involving 46 hospitalized COVID-19 patients tested three doses of plitidepsin and primarily focused on safety, while also monitoring viral load changes, mortality, and need for respiratory support.
- - The treatment was generally safe, with some common side effects like nausea, vomiting, and diarrhea; early results indicated significant reductions in viral load over time, though a few patients required additional medical support.
Unlabelled: Plitidepsin is a marine-derived cyclic-peptide that inhibits SARS-CoV-2 replication at low nanomolar concentrations by the targeting of host protein eEF1A (eukaryotic translation-elongation-factor-1A). We evaluated a model of intervention with plitidepsin in hospitalized COVID-19 adult patients where three doses were assessed (1.5, 2 and 2.
View Article and Find Full Text PDFBackground: is the leading cause of prosthetic joint infection (PJI). Beyond the antibiogram, little attention has been paid to the influence of deep microbiological characteristics on patient prognosis. Our aim was to investigate whether microbiological genotypic and phenotypic features have a significant influence on infection pathogenesis and patient outcome.
View Article and Find Full Text PDFA 70-year-old lady with diabetes and monoclonal gammopathy underwent pacemaker implant for 2:1 atrioventricular block. Within 7 days, a painful, infiltrating, necrotic lesion involved the implant area. Biopsy was compatible with pyoderma gangrenosum and corticosteroid treatment led to healing in 3 weeks.
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