Liver Transplant and Incisional Hernia: What Do We Know and What Can We Improve.

Background: During follow-up, incisional hernias can reduce the quality of life of transplant recipients. The objective was to analyze the incidence of incisional hernia and risk factors to detect improvements.

Methods: Retrospective study of transplant recipients between 2002 and 2021.

A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensive care unit.

To determine whether IV melatonin therapy improves redox status and inflammatory responses in surgical patients with severe sepsis, a unicenter, phase II double-blind, randomized, placebo-controlled trial was carried out. The study included patients with severe sepsis marked by infectious systemic inflammatory response syndrome (SIRS), associated with organ dysfunction, hypoperfusion or hypotension requiring surgical intervention. IV melatonin at a daily dose of 60 mg, which was dissolved in 500 ml of 5% dextrose serum, was continuously administered to the patients for over 30 min starting on the day of the diagnoses during a 5-day period.

[Traumatic diaphragmatic rupture].

Traumatic diaphragmatic rupture is an infrequent lesion that can result from penetrating or blunt trauma to the abdomen or chest. Early diagnosis continues to be a challenge and this type of injury is associated with high morbidity and mortality. Preoperative diagnosis is difficult and a high level of suspicion, careful scrutiny of the chest x-ray, and early surgical treatment are required for successful management.

Positron-emission tomography with fluorine-18-fluoro-2-deoxy-D-glucose for gallbladder cancer diagnosis.

Background: Recent advances in hepatobiliary surgery have underscored the need for presurgical diagnosis of gallbladder cancer. Frequently, clinical presentation, biochemical analysis, and structural ultrasound or computed axial tomography images do not enable definitive differentiation of cholecystitis or cholethiasis from gallbladder cancer. The aim of this study was to evaluate the role of fludeoxy glucose-positron-emission tomography (FDG-PET) in establishing the benign or malignant nature of gallbladder lesions.

Effect of pretreatment with interleukin-1 beta on inflammatory infiltrates and tissue damage after experimental endotoxic challenge.

Objective: To evaluate the effect of treatment with murine recombinant interleukin-1 beta on inflammatory infiltrate and tissue damage after experimental endotoxic challenge.

Design: Randomized, controlled study.

Setting: Experimental Unit, Virgen de las Nieves University Hospital.