Publications by authors named "Alfonso B Demur"
Emerging evidence has shown that assortative mating (AM) is a key factor that shapes the landscape of complex human traits. It can increase the overall prevalence of disorders, influence occurrences of comorbidities, and bias estimation of genetic architectures. However, there is lack of large-scale studies to examine the cultural differences and the generational trends of AM for psychiatric disorders.
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- Mitochondrial DNA haplogroups (mtDNA hgs) show distinct geographical distributions and have been linked to certain diseases, though these links are often inconsistent.
- Using a large dataset from Denmark (24,642 dried blood spots), researchers examined mtDNA variation and found evidence of diverse origins, suggesting multiple waves of population migration.
- The study reveals significant changes in mtDNA hgs over time, likely driven by immigration, which complicates the understanding of their associations with health outcomes across different populations.
Article Synopsis
- Mitochondria are linked to human diseases, but it's challenging to replicate connections between mitochondrial DNA (mtDNA) SNPs and diseases like schizophrenia.
- A study involving almost 26,000 individuals found significant differences in mtDNA haplogroups and nuclear ancestry between healthy individuals and schizophrenia patients.
- Only two specific mtDNA SNPs showed an initial association with schizophrenia, but these links disappeared when considering the haplogroup and nuclear ancestry factors, highlighting the complexities in interpreting mtDNA studies.