Publications by authors named "Alfonsina Mirabal Santos"
Am J Cardiol
October 2024
Article Synopsis
- * The study found that anemia linked to higher risks for all-cause and cardiovascular hospitalizations, with significant statistics demonstrating this correlation.
- * Despite the correlation, when adjusting for age and other factors, anemia was mainly associated with an increased hazard for hospitalizations rather than mortality, highlighting the need for more research on how treating anemia might improve patient outcomes.
J Card Fail
December 2024
Article Synopsis
- A study was conducted to evaluate the safety and effectiveness of sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with amyloid light-chain cardiomyopathy (AL-CM), a condition linked to heart failure.
- In the study, 27 AL-CM patients were analyzed for adverse events and efficacy, with a subset of 17 patients compared to 21 untreated controls to assess changes in disease markers.
- Results indicated that while there were some mild adverse events, SGLT2i treatment led to significant improvements in reducing loop diuretic use and lowering NTproBNP levels in the treated group compared to controls.
Eur J Heart Fail
April 2024
Article Synopsis
- A retrospective study evaluated the short-term effectiveness and safety of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with transthyretin amyloid cardiomyopathy (ATTR-CM), as previous randomized trials had excluded these individuals.
- The study involved 87 ATTR-CM patients on SGLT2i and 95 untreated control patients, measuring changes in weight, diuretic dosage, and cardiac/renal biomarkers.
- SGLT2i treatment significantly improved weight and diuretic use, with most patients tolerating the treatment well, although 11.5% discontinued it due to side effects; further randomized trials are needed for validation.
Article Synopsis
- Transthyretin cardiac amyloidosis (ATTR cardiac amyloidosis) affects older adults and can cause gait abnormalities, yet there is limited research focused on this demographic.
- A study involving 28 older males with ATTR cardiac amyloidosis and 11 healthy controls found significant differences in gait patterns, with the patients demonstrating slower, narrower, and shorter strides.
- Despite the gait differences observed in ATTR cardiac amyloidosis patients, these variations did not correlate with the severity of their clinical condition, indicating that gait analysis can be a useful tool for assessing falls risk and improving patient care.
