Publications by authors named "Alfiya Odintsova"
Crohn's disease (CD) is a chronic relapsing inflammatory bowel disease of unknown etiology. Genetic predisposition and dysbiotic gut microbiota are important factors in the pathogenesis of CD. In this study, we analyzed the taxonomic composition of the gut microbiota and genotypes of 24 single nucleotide polymorphisms (SNP) associated with the risk of CD.
View Article and Find Full Text PDFThis article presents the clinical case of a patient with a long history of ulcerative colitis. Seven years after the onset of the disease, other autoimmune disorders such as sacroiliitis and alopecia have manifested. Ulcerative colitis is characterized by severe exacerbations, development of steroid resistance, ineffectiveness of mesalazine therapy, and onset of leukopenia when taking azathioprine and 6-mercaptopurine.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers sequenced genomes from 63 gut strains of CD patients and healthy individuals, revealing similar genetic traits related to virulence and antibiotic resistance.
- * Findings indicate competitive bacteria interactions in the gut that could potentially harm the host, highlighting the complex dynamics of gut microbiota in CD.
Article Synopsis
- This study explores the gut microbiota and IBD biomarkers in patients from Kazan, Russia, addressing the growing interest in IBD in newly industrialized countries.* -
- Researchers found significant changes in the gut microbiota of IBD patients, including increased levels of certain bacteria and decreased levels of beneficial species, indicating a dysbiotic state.* -
- The findings suggest that these changes, particularly the imbalance of short-chain fatty acids (SCFAs), may impact important metabolic processes like hydrogen metabolism, which is crucial for understanding the disease.*