Nornidulin, A New Inhibitor of Malate: Quinone Oxidoreductase (MQO) from Indonesian sp. BioMCC f.T.8501.

This study aimed to obtain a microbial active compound as a novel antimalarial drug from Indonesian isolates. Target-based assays were used to screen for antimalarial activity against the parasite mitochondrial, malate:quinone oxidoreductase (MQO) enzyme. In total, 1600 crude extracts, composed from 800 fungi and 800 actinomycetes extracts, were screened against MQO, yielding six active extracts as primary hits.

Effect of Metabolite Extract of subsp. on 3D7 in Vitro.

Background: Malaria eradication has been complicated by the repeated emergence of antimalarial drug resistances. We aimed to determine whether a metabolite extract of subsp. could decrease the viability of 3D7 in vitro.