Publications by authors named "Alfiah Amiruddin"
Ann Med Surg (Lond)
August 2023
Article Synopsis
- - The high mortality rate in breast cancer patients is often linked to metastases that resist systemic therapies, with circulating miRNAs-221 and miR-222 identified as key factors in this resistance by promoting cancer cell growth and survival.
- - A study involving luminal subtype breast cancer patients treated with tamoxifen found that miR-221 levels significantly differed between patients with local recurrence and those without, indicating its potential role in predicting tamoxifen resistance.
- - The findings suggest that measuring circulating miR-221/222 could help identify breast cancer patients at risk for treatment failure with tamoxifen, enabling earlier intervention and more effective treatment strategies.
Ann Med Surg (Lond)
January 2022
Article Synopsis
- - Approximately 70% of breast cancers are estrogen receptor-α (ERα)-positive, and tamoxifen, a selective ER modulator, is commonly used in treatment, but resistance to it can occur, often involving microRNAs like miR-221.
- - A study compared breast cancer patients with and without local or metastatic recurrence after at least one year of tamoxifen therapy, focusing on the expression levels of miR-221.
- - Results showed significantly higher expression of miR-221 in tamoxifen-resistant cases, suggesting that miR-221 may serve as a potential biomarker for predicting resistance to tamoxifen treatment in breast cancer patients.
