[An experimental study of the amides of aromatic carboxylic acids as radiosensitizing agents].

In experiments with mice a study was made of the radiosensitizing efficacy of 10 aromatic carbonic acid amides, benzene, naphthalene, pyridine and quinoline derivatives. It has been found, for this group of substances, that there is a direct correlation between the ability of the substance to reduce the splenic endocolonies production and the inhibitory activity with regard to poly(ADP-ribose) polymerase of thymocyte nuclei. Within the group of substances under study, new agents are found and described and new relationships are revealed between their chemical structure and biological activity.

[Radioprotective activity of complexes of copper, cobalt and zinc with substituted acylhydrazones].

Acylhydrazone metal complexes belong to a new class of radioprotective agents that have a cytostatic effect increasing, in some cases, the survival rate of irradiated animals by 40-60 per cent compared to irradiated controls. The most active drugs are hypotoxic and applied in much lower doses than ordinary S-containing radioprotective agents to achieve the same protective effect.

[Radioprotective efficacy of acyl hydrazones].

As was shown in experiments with rats and mice some acyl hydrazones have a pronounced radioprotective effect. The protective efficiency makes 40-55 per cent with the preparation doses of 1-10 mg/kg. The toxicity of hydrazones is 2 g/kg which is lower, than that of the known sulfur-containing agents and substituted indolylalkylamines.

[Radio-protective effect of sulfur-containing methylfuran derivatives and the role of thiols in its realization].

In experiments on mice it was demonstrated that S-containing methylfuran derivatives were highly radioprotective (50-70% survival of exposed animals). The preparations under study did not influence the redox potential in tissues and did not change the content of nonprotein SH-groups in the radiosensitive organs.