Publications by authors named "Alfano Alessandro"
Article Synopsis
- A 12-year-old child with an optic disk pit underwent surgery to treat a macular detachment, using a specialized technique involving an inverted ILM flap.
- Post-operative OCT-angiography revealed notable features, including areas of capillary dropout and star-shaped folds in the retina and choroid, indicating changes in blood flow and structure.
- Two years after surgery, OCT-angiography showed improved macular blood flow, which aligned with the child's full recovery of visual acuity, highlighting the effectiveness of this imaging method for monitoring recovery in similar cases.
The efficacy of intravitreal anti-VEGF may be reduced in vitrectomized eyes due to accelerated drug clearance. Given its longer durability, brolucizumab may represent a suitable therapeutic option. However, its efficacy in vitrectomized eyes remains to be explored.
View Article and Find Full Text PDFThe debate around unmet clinical need (UCN) is still very much alive. How do we define UCN? How does it influence the definition of clinically relevant outcomes in a therapeutic area? Who defines UCN? What are the consequences of recognizing different grading of UCN? In this paper we will address these questions and finally formulate proposals for the Italian context. The paper is based on a discussion within a panel of experts.
View Article and Find Full Text PDFArticle Synopsis
- - A 53-year-old man with seronegative arthritis developed significant eye issues, including inflammation and cystoid macular edema, leading to a diagnosis of noninfectious uveitis and treatment with prednisolone.
- - After some initial improvement, his condition worsened, resulting in retinal hemorrhages and lesions that were unusual in appearance, prompting further investigation.
- - Ultimately, he was diagnosed with Whipple's disease, highlighting that ocular symptoms can occur even in the absence of gastrointestinal issues and can present with distinctive eye-related complications.
Purpose: To investigate the microstructural changes after successful myopic macular hole (MMH) surgery, comparing inverted ILM flap and complete ILM removal techniques, and their association with visual function.
Methods: Spectral-domain optical coherence tomography (SD-OCT) was used to evaluate both external limiting membrane (ELM) and ellipsoid zone (EZ) recovery in 40 eyes of 39 patients who underwent pars plana vitrectomy with either inverted internal limiting membrane flap technique (=27) or complete ILM removal (=13) to achieve MH closure. The association between ELM and EZ recovery and visual acuity was also investigated.
Purpose: To investigate if the contiguity between native and transplanted retinal pigment epithelium (RPE) represents a protective factor against the progression of atrophy after autologous choroidal graft. In addition, the changes in fundus autofluorescence (FAF) in the contiguous and noncontiguous RPE areas were explored.
Methods: The first postoperative reliable FAF image was selected and divided into sectors based on the characteristics of the RPE at the edge of the graft.
Background: Indocyanine Green Angiography (ICG-A) and Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography (EDI-OCT) are essential imaging techniques for diagnosis, management and understanding of the pathophysiology of many chorioretinal diseases. Herein, we report the ICG-A and EDI-OCT findings from a case of Acute Posterior Multifocal Placoid Pigment Epitheliopathy (APMPPE), in which these imaging techniques enable the visualization of more diagnostic details than those observable with other widely used diagnostic tools.
Case Presentation: A 60-year-old white female presented with bilateral blurred vision for few days.
Purpose: To compare the results of vitrectomy with complete internal limiting membrane (ILM) removal and inverted ILM flap in the treatment of myopic macular hole (MMH).
Methods: Seventy eyes of 68 patients with MMH undergone pars-plana vitrectomy (PPV) with either complete ILM removal (n = 36, Group 1) or inverted ILM flap technique (n = 34, Group 2) were included in the study. Outcomes measured were the rate of MMH closure assessed by optical coherence tomography (OCT) and visual acuity (BCVA) at six months.