Publications by authors named "Alf Henrik Engman"
Article Synopsis
- The study presents a method to create small, high-affinity proteins (VH domains) for targeting drug interactions inside cells, overcoming challenges of stability and expression.
- Researchers developed a unique VH domain that can function without disulfide bonds and created a diverse library for effective screening.
- Identified VH domains showed strong binding to a cancer-related protein, eIF4E, and their intracellular use led to reduced cancer cell growth and malignancy markers.
