Publications by authors named "Alexzander A A Asea"
Article Synopsis
- Mesoangioblasts are specialized stem cells linked to blood vessels, showing potential for tissue regeneration due to their ability to differentiate into various cell types.
- Their movement into injured tissues is influenced by cytokines and inflammatory factors, but the specific mechanisms for crossing the extracellular matrix (ECM) were largely unknown.
- The study reveals that Hsp70, released from mesoangioblasts, aids in their migration through ECM by interacting with receptors TLR4 and CD91, and it regulates enzymes MMP2 and MMP9, with MMP2 playing a key role in cell migration.
Type 2 diabetes is a growing public health concern and accounts for approximately 90% of all the cases of diabetes. Besides insulin resistance, type 2 diabetes is characterized by a deficit in β-cell mass as a result of misfolded human islet amyloid polypeptide (h-IAPP) which forms toxic aggregates that destroy pancreatic β-cells. Heat shock proteins (HSP) play an important role in combating the unwanted self-association of unfolded proteins.
View Article and Find Full Text PDFHeat shock proteins in physiology and pathology: the Berlin meeting.
Cell Stress Chaperones
October 2007