Publications by authors named "Alexus Williams"
Obesity increases the risk for stroke and is associated with worse post-stroke outcomes; however, the mechanisms are poorly understood. Diet-induced obesity leads to insulin resistance and subsequently, brain insulin deficiency. The purpose of this study was to investigate the potential impact of brain insulin deficiency on post-stroke outcomes.
View Article and Find Full Text PDFArticle Synopsis
- Insulin receptors in brain endothelial cells are crucial for their functioning, but the effects of high insulin levels (hyperinsulinemia) on these receptors are not well understood.
- The study focused on how hyperinsulinemia affects insulin receptor internalization by examining phosphorylation changes and the role of protein tyrosine phosphatase 1B (PTP1B) using brain microvessels from mice on a high-fat diet.
- Findings revealed that hyperinsulinemia leads to increased insulin receptor levels but decreased signaling, suggesting that alternative splicing and PTP1B's negative feedback influence this disruption; however, using the PTP1B antagonist Claramine could restore signaling and receptor internalization.
Riding the wave: a quantitative report of electrocardiogram utilization for myocardial infarction confirmation.
Am J Physiol Heart Circ Physiol
September 2022
The purpose of this study was to generate a quantitative profile of electrocardiograms (ECGs) for confirming surgical success of permanent coronary artery ligation. An ECG was recorded at baseline, and 0, 1, and 5 min after ligation and analyzed using iWorkx LabScribe software. (C57Bl6/J, = 8/sex) was enrolled to determine ECG characteristics that were confirmed in (C57Bl6/J, = 6/sex; = 6 males/4 females).
View Article and Find Full Text PDFObesity, neurodegenerative diseases, and injury can all lead to cognitive deficits, which can be improved clinically with the implementation of cognitive rehabilitation. Due to a lack of effective cognitive rehabilitation tools in mice, we re-designed a cognitive task utilized to detect problem-solving deficits, to develop a cognitive rehabilitation paradigm for mice. In this study, we developed a modified the Puzzle Box task by exposing B6 mice to a variety of obstacles and assessing the escape latencies.
View Article and Find Full Text PDFResearch on the impact of diet and memory has garnered considerable attention while exploring the link between obesity and cognitive impairment. High-fat diet (HFD) rodent models recapitulate the obesity phenotype and subsequent cognitive impairments. While it is known that HFD is associated with sensory impairment, little attention has been given to the potential role these sensory deficits may play in recognition memory testing, one of the most commonly used cognitive tests.
View Article and Find Full Text PDFState regulatory efforts in protecting a surrogate's bodily autonomy.
Seton Hall Law Rev
January 2019