Nutrients
February 2023
Endotoxemia is a condition caused by increasing levels of lipopolysaccharide (LPS) characterized by an impaired systemic response that causes multiple organ dysfunction. ATCC 9595 is a strain with probiotic potential which shows immunomodulatory properties. The incorporation of this bacterium in food rich in bioactive compounds, such as cupuaçu juice (), could result in a product with interesting health properties.
View Article and Find Full Text PDFMalaria represents a significant public health burden to populations living in developing countries. The disease takes a relevant toll on pregnant women, who are more prone to developing severe clinical manifestations. Inflammation triggered in response to sequestration inside the placenta leads to physiological and structural changes in the organ, reflecting locally disrupted homeostasis.
View Article and Find Full Text PDFThere is currently a global effort to reduce malaria morbidity and mortality. However, malaria still results in the deaths of thousands of people every year. Malaria is caused by Plasmodium spp.
View Article and Find Full Text PDFPathogens
January 2020
Vulvovaginal candidiasis is a common fungal infection in women. In this study, hydroalcoholic extract (PiHE) and its fractions were evaluated for antifungal and antivirulence activities against vaginal species. Dichloromethane (DCMF) and ethyl acetate fractions (EAF) obtained from PiHE effectively inhibited the pathogen.
View Article and Find Full Text PDFBiomolecules
December 2019
Skin injuries constitute a gateway for pathogenic bacteria that can be either part of tissue microbiota or acquired from the environmental. These microorganisms (such as and ) produce virulence factors that impair tissue integrity and sustain the inflammatory phase leading for establishment of chronic wounds. The high levels of antimicrobial resistance have limited the therapeutic arsenal for combatting skin infections.
View Article and Find Full Text PDFThe occurrence of damage on bacterial DNA (mediated by antibiotics, for example) is intimately associated with the activation of the SOS system. This pathway is related to the development of mutations that might result in the acquisition and spread of resistance and virulence factors. The inhibition of the SOS response has been highlighted as an emerging resource, in order to reduce the emergence of drug resistance and tolerance.
View Article and Find Full Text PDFThe latex of L. (LET) has great etnopharmacological relevance for several traditional communities. In this study, the and (using larvae) antimicrobial effects of LET were evaluated.
View Article and Find Full Text PDFBMC Complement Altern Med
October 2018
Background: Spondias tuberosa is a plant that produces a fruit crop with high economic relevance at Brazilian Caatinga. Its roots and leaves are used in folk medicine.
Methods: Chemical composition of a hexane extract from S.