Aging is a major risk factor for vascular cognitive impairment and dementia (VCID). Recent studies demonstrate that cerebromicrovascular dysfunction plays a causal role in the development of age-related cognitive impairment, in part via disruption of neurovascular coupling (NVC) responses. NVC (functional hyperemia) is responsible for adjusting cerebral blood flow to the increased energetic demands of activated neurons, and in preclinical animal models of aging, pharmacological restoration of NVC is associated with improved cognitive performance.
View Article and Find Full Text PDFPurpose: To demonstrate the efficacy and safety of once-daily nepafenac 0.3% ophthalmic suspension versus vehicle, based on clinical outcomes, after cataract surgery in patients with diabetes.
Design: Two prospective, randomized, multicenter, double-masked, vehicle-controlled phase 3 studies.
Purpose: To analyze the effect of the accommodation on the anterior segment data (corneal and anterior chamber parameters) induced by short-time reading in a healthy, nonpresbyopic adult patient group.
Methods: Images of both eyes of nonpresbyopic volunteers were captured with a Scheimpflug device (Pentacam HR) in a nonaccommodative state. Fifteen minutes of reading followed and through fixation of the built-in target of Pentacam HR further accommodation was achieved and new images were captured by the device.
Purpose: To compare the intraocular pressure (IOP)-lowering efficacy and safety of brinzolamide 1% and brimonidine 0.2% fixed combination (BBFC) with that of brinzolamide 1% or brimonidine 0.2% monotherapy, all dosed 2 times per day (BID).
View Article and Find Full Text PDFPurpose: To evaluate once-daily nepafenac 0.3% to prevent and treat ocular pain and inflammation after cataract surgery.
Setting: Sixty-five centers in the United States and Europe.
Unlabelled: Some patient with monofocal intraocular lens can achieve good near visual acuity with distance correction after cataract surgery. Understanding and measuring this phenomenon also called pseudoaccommodation can help to develop new technology to substitute or restore accommodation in pseudophakic eyes.
Aim: I.
J Cataract Refract Surg
September 2007
Purpose: To evaluate anterior segment alterations with age and during accommodation in different age groups.
Setting: Department of Ophthalmology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.
Methods: Fifty-three subjects (101 normal eyes) were enrolled in this study and divided into 3 age groups: younger than 30 years (Group 1), between 31 years and 44 years (Group 2), and older than 45 years (Group 3).
Purpose: To measure anterior chamber depth (ACD) with an anterior segment optical coherence tomography (AS-OCT) and a standard ultrasonic (US) axial scan (A-scan) device using an immersion technique and to assess repeatability, reproducibility, and correlations of the measurements.
Setting: Department of Ophthalmology, Medical Health and Science Center, University of Debrecen, Debrecen, Hungary.
Methods: Sixty healthy eyes of 41 patients were enrolled in a study.
Purpose: To understand the source and evolution of the cellular elements of posterior capsule plaques.
Setting: Department of Ophthalmology, University of Sciences, Faculty of Medicine, Pécs, Hungary.
Methods: In 24 eyes of 24 patients, the primary fibrotic plaques were carefully peeled off the posterior capsule with forceps and sent for histological examination.
Purpose: To distinguish pseudophakic accommodation from pseudoaccommodation by measuring the physiologically and pharmacologically induced anterior chamber depth (ACD) shifts.
Setting: Department of Ophthalmology, University of Debrecen, Debrecen, Hungary.
Methods: This study comprised 100 pseudophakic eyes of 79 patients.
Purpose: To compare central corneal thickness (CCT) values obtained with ultrasonic pachymetry and a new optical method using partial coherence interferometry (PCI).
Setting: Department of Ophthalmology, Medical Health and Science Center, University of Debrecen, Debrecen, Hungary.
Methods: The study comprised 136 eyes of 70 patients whose spherical refractive error was not greater than +/-6.