Publications by authors named "Alexis R Morales"
Article Synopsis
- Pharmacogenomics (PGx) is a growing field in developing countries, particularly in Latin America and the Caribbean (LAC), but research and information are limited, making it challenging to apply findings across diverse populations.
- The study reviewed PGx knowledge among the LAC scientific community, identified barriers to its clinical use, and surveyed 106 professionals to evaluate these obstacles, revealing that the primary barrier is the lack of guidelines for implementing PGx in practice.
- Despite these challenges, LAC has contributed 3.44% of global PGx publications and identified gene/drug pairs, such as tamoxifen and clopidogrel, as significant for improving genomic medicine responses, although cost-effectiveness concerns remain a critical issue.
Carbamazepine (CBZ) is an oral anticonvulsant drug, structurally similar to tricyclic antidepressants. It is preferred over other drugs because it has fewer adverse effects on behavior and alertness. However, hematologic toxicity is possible during therapy with CBZ.
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