Publications by authors named "Alexis Mancini"

Significance: Mantle cell lymphoma (MCL) is a rare lymphoma that can present even more rarely in the orbit. Diagnosis, differentiation, and systemic treatment with the help of an oncologist are necessary for improved prognosis. Eye care providers must be vigilant when addressing ocular findings to determine next steps.

View Article and Find Full Text PDF

The time-dependent bioadhesive performance of various polymers was evaluated using a texture analyzer apparatus and freshly excised rat small intestinal tissue. A series of novel bioadhesive polymers were prepared by conjugating L-phenylalanine, L-tyrosine, and L-DOPA to either a low molecular weight poly (butadiene-maleic anhydride) or a high molecular weight poly (ethylene-maleic anhydride). Bioadhesive force was characterized as a function of time relative to polycarbophil, a slightly cross-linked poly (acrylic acid)-derivative, revealing different fracture strengths and tensile work for each of the six backbone-side chain conjugations that were studied.

View Article and Find Full Text PDF

The one-step synthesis and characterization of novel bioinspired bioadhesive polymers that contain Dopa, implicated in the extremely adhesive byssal fibers of certain gastropods, is reported. The novel polymers consist of combinations of either of two polyanhydride backbones and one of three amino acids, phenylalanine, tyrosine, or Dopa, grafted as side chains. Dopa-grafted hydrophobic backbone polymers exhibit as much as 2.

View Article and Find Full Text PDF

Synopsis of recent research by authors named "Alexis Mancini"

  • - Alexis Mancini's research predominantly focuses on the development and evaluation of bioadhesive polymers, particularly those modified with amino acids such as Dopa, phenylalanine, and tyrosine to enhance adhesion properties in biomedical applications.
  • - Recent findings demonstrate novel formulations of bioadhesive polymers that exhibit varying fracture strengths and tensile work, highlighting their potential for use in drug delivery and other therapeutic applications.
  • - Additionally, Mancini has contributed to the understanding of rare medical conditions, such as the ocular manifestations of mantle cell lymphoma, emphasizing the need for collaboration between eye care providers and oncologists to improve patient outcomes.