Publications by authors named "Alexis C Harold"
Article Synopsis
- Pancreatic cancer is highly lethal and involves complex changes in the tumor microenvironment and metabolism, which researchers aimed to understand using single-cell RNA-sequencing from human pancreas samples.
- The study found that cancer cells showed increased biosynthesis, while immune cells displayed a downregulation of mitochondrial functions, indicating specific metabolic alterations among different cell types.
- Researchers also discovered that tumor-associated macrophages (TAMs) might supply cholesterol to cancer cells, suggesting a possible new mechanism for cancer growth and a potential target for future therapies.
