Publications by authors named "Alexis B Sandler"

Article Synopsis
  • Suprascapular nerve decompression (SSND) has been a debated surgical procedure, with earlier studies indicating good outcomes, but recent evidence showing limited benefits when added to other surgeries.
  • This systematic review analyzed 33 studies involving 730 patients to assess patient outcomes after SSND, focusing on clinical improvements, return to sports, and potential complications.
  • Results demonstrated significant postoperative improvements in multiple shoulder assessment scores, with 98% of patients returning to their previous level of activity, although 12% still reported ongoing symptoms.
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Background: Anterior humeral avulsions of the glenohumeral ligament (aHAGL) lesions are relatively rare causes of shoulder instability that affect athletes at a higher rate than other populations. The purpose of this study is to evaluate rate of return to sport (RTS) after HAGL repair.

Methods: A search of the PubMed (MEDLINE), Scopus, and Cochrane CENTRAL databases was conducted on April 13, 2022 with the search terms "HAGL" or "humeral avulsion glenohumeral ligament" was used to conduct the systematic review.

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Background: In the setting of total knee arthroplasty (TKA), prior patellectomy historically prompted the use of increased constraint implants, specifically posterior-stabilized (PS) designs. However, modern case series have reported similar outcomes utilizing cruciate-retaining (CR) implants. The primary outcome of this study was to compare implant retention rates between these 2 implant designs in prior patellectomy patients.

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Background Elbows are one of the most frequently dislocated large joints; however, there is limited epidemiological data, especially during the coronavirus disease 2019 (COVID-19) pandemic. This study characterizes elbow dislocations presenting to Emergency Departments (EDs) over the last decade. Methods This study is a cross-sectional, descriptive, epidemiologic analysis of isolated elbow dislocations presenting to EDs from 2011-2020 using the National Electronic Injury Surveillance System (NEISS) database.

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Background: Given the rising prevalence of obesity, the number of patients with obesity undergoing arthroscopic rotator cuff repair (RCR) will likely increase; however, there have been mixed results in the existing literature with regard to the effect of elevated body mass index (BMI) on functional outcomes and complications.

Methods: The patient-reported outcome measures included the visual analog scale (VAS) pain score, the American Shoulder and Elbow Surgeons (ASES) score, range of motion, and adverse events.

Results: Fourteen studies (118,331 patients) were included.

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Background: While concomitant rotator cuff and inferior labral tears are relatively uncommon in young civilians, military populations represent a unique opportunity to study this injury pattern.

Purpose: To (1) evaluate the long-term outcomes after combined arthroscopic rotator cuff and inferior labral repair in military patients <40 years and (2) compare functional outcomes with those after isolated arthroscopic rotator cuff repair.

Study Design: Cohort study; Level of evidence, 3.

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Purpose: To evaluate the reliability of the "perfect-circle" methodology for measurement of glenoid bone loss with magnetic resonance imaging (MRI) in patients with posterior glenohumeral instability.

Methods: A prospective chart review was performed on patients who underwent isolated arthroscopic posterior labral repairs in our institution's electronic medical records between January 1, 2021, and June 30, 2021. Inclusion criteria included isolated posterior shoulder instability with posterior labral repair and corroborated tears on MRI.

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Background: Distal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types: Supracondylar (SC), lateral condyle (LC), and medial epicondyle (ME) fractures.

Aim: To evaluate the epidemiology of pediatric distal humerus fractures (SC, LC, and ME) from an American insurance claims database.

Methods: A retrospective review was performed on patients 17 years and younger with the ICD 9 and 10 codes for SC, LC and ME fractures based on the IBM Truven MarketScan Commercial and IBM Truven MarketScan Medicare Supplemental databases.

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Background: Posterior glenohumeral instability is an increasingly recognized cause of shoulder pain and dysfunction among young, active populations. Outcomes after posterior stabilization procedures are commonly assessed using patient-reported outcome measures including the Single Assessment Numeric Evaluation (SANE), the Rowe instability score, the American Shoulder and Elbow Surgeons (ASES) score, and the visual analog scale (VAS) for pain. The clinical significance thresholds for these measures after arthroscopic posterior labral repair (aPLR), however, remain undefined.

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Article Synopsis
  • Military patients experience high rates of shoulder issues like glenohumeral instability and SLAP tears, with a notable coexistence of these injuries.
  • This study aims to assess the outcomes of combining biceps tenodesis with anterior labral repair in military patients under 40, comparing it to isolated labral repair outcomes.
  • Results show that 82 active-duty patients were analyzed, revealing significant differences in preoperative pain levels but no major differences in outcomes between the two surgical approaches during follow-up.
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Background: Posterior instability has been reported to account for up to 24% of cases of shoulder instability in certain active populations. However, there is a paucity of data available regarding the risk factors associated with posterior glenoid bone loss.

Purpose: To characterize the epidemiology of, and risk factors associated with, glenoid bone loss within a cohort of patients who underwent primary arthroscopic shoulder stabilization for isolated posterior-type glenohumeral instability.

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Background: While concomitant full-thickness rotator cuff tears and glenoid osteochondral defects are relatively uncommon in younger patients, military patients represent a unique opportunity to study this challenging injury pattern.

Purpose/hypothesis: To compare the outcomes of young, active-duty military patients who underwent isolated arthroscopic rotator cuff repair (ARCR) with those who underwent ARCR plus concurrent glenoid microfracture (ARCR+Mfx). It was hypothesized that ARCR+Mfx would produce significant improvements in patient-reported outcome measures.

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Background: There is a paucity of current data regarding the sport-specific injury patterns and epidemiological trends associated with volleyball.

Purpose: To provide an updated, comparative assessment of the epidemiology of volleyball-related injuries among female high school- and college-aged athletes and to characterize the burden of these injuries on emergency departments (EDs) across the United States.

Study Design: Descriptive epidemiological study.

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Background: US military servicemembers experience higher rates of posterior and combined-type instability as compared with their nonmilitary peers.

Purpose: (1) To determine the prevalence of glenoid bone loss (GBL) in young, active-duty military patients with combined-type shoulder instability who underwent operative shoulder stabilization; (2) to evaluate whether GBL is associated with differences in postoperative outcomes; and (3) to identify factors associated with larger defects.

Study Design: Case series; Level of evidence, 4.

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Background: Large variations exist in the reported frequency and etiology of posterior and combined shoulder instability in the active-duty military population.

Purpose: To compare imaging and clinical examination findings as well as reoperation rates between active-duty military patients who underwent surgery for anterior, posterior, and combined-type shoulder instability.

Study Design: Cross-sectional study; Level of evidence, 3.

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Background: Members of the military are known to experience disproportionately high rates of both glenohumeral instability and superior labrum anterior-posterior (SLAP) tears when compared with civilian populations. Although the outcomes after simultaneous repair of Bankart and SLAP lesions have been well described, there is a paucity of literature available regarding the operative management of posterior instability with concomitant superior labral pathology.

Purpose: To compare outcomes of combined arthroscopic posterior labral and SLAP repair with those of isolated posterior labral repair.

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Background: Epidemiological understanding of acute sternoclavicular (SC) dislocations secondary to sports across the United States is poorly defined.

Aim: To identify and assess epidemiological trends of SC dislocations occurring secondary to sports-related mechanisms across United States over the past two decades.

Methods: This cross-sectional, descriptive epidemiological study evaluates epidemiological trends of SC dislocations from sports that present to emergency departments (EDs) across the United States.

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Background: In recent years, the placement of a subacromial balloon (SAB) spacer has emerged as a treatment option for massive irreparable rotator cuff tears (MIRCTs); however, there is significant controversy regarding its utility in comparison with other surgical interventions.

Purpose: To compare outcomes after SAB spacer placement versus arthroscopic debridement for MIRCTs.

Study Design: Dual-armed systematic review and meta-analysis (level IV evidence).

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Background: Superior labrum anterior-posterior (SLAP) lesions and anterior instability are common causes of shoulder pain and dysfunction among active-duty members of the United States military. However, little data have been published regarding the surgical management of type V SLAP lesions.

Purpose: To compare the outcomes of arthroscopic-assisted subpectoral biceps tenodesis and anterior labral repair with those of arthroscopic SLAP repair (defined as contiguous repair spanning from the superior labrum to the anteroinferior labrum) for type V SLAP tears in active-duty military patients younger than 35 years.

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Article Synopsis
  • * Silencing NR2F2 in human endothelial cells causes inflammation, increased cell migration, resistance to apoptosis, and changes related to vascular damage, while also elevating DKK1 levels, which is associated with pulmonary arterial hypertension.
  • * Therapeutic strategies that either activate NR2F2 or block DKK1 might offer potential treatments for chronic vascular diseases linked to endothelial cell dysfunction.
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Synopsis of recent research by authors named "Alexis B Sandler"

  • Recent research by Alexis B Sandler focuses on various aspects of orthopedic surgery, particularly related to shoulder injuries, knee arthroplasty, and pediatric fractures, revealing significant insights into surgical outcomes and complications.
  • Notable findings include an updated systematic review highlighting high return-to-sport rates after suprascapular nerve decompression and investigating the impact of obesity on outcomes following arthroscopic rotator cuff repairs.
  • Additional studies analyze the efficacy of surgical techniques and assess epidemiological trends in elbow dislocations and pediatric humeral fractures, providing essential data for improving clinical practices.

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