Publications by authors named "Alexie A Carletti"
Article Synopsis
- RECON is an oxidoreductase that senses cyclic dinucleotides (CDNs) from bacteria, inhibiting its own enzymatic activity and promoting inflammation.
- The study showed that in cells lacking RECON, there was increased cell-to-cell spread of an intracellular bacterium, which was not linked to key virulence factors.
- The findings suggest that RECON normally suppresses inflammatory responses, and its inhibition by bacterial c-di-AMP leads to enhanced NF-κB activation, increased nitric oxide production, and ultimately more effective bacterial spreading.
