Publications by Alexia S Puerta Cordova

Publications by authors named "Alexia S Puerta Cordova"

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A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy.

Dan A Tudorica Bishal Basak Alexia S Puerta Cordova Grace Khuu Kevin Rose

J Cell Biol

July 2024

Activation of PINK1 and Parkin in response to mitochondrial damage initiates a response that includes phosphorylation of RAB7A at Ser72. Rubicon is a RAB7A binding negative regulator of autophagy. The structure of the Rubicon:RAB7A complex suggests that phosphorylation of RAB7A at Ser72 would block Rubicon binding.

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