Synopsis of recent research by authors named "Alexia Carre"
- Alexia Carre's recent research primarily focuses on the interactions between viral infections, particularly Coxsackievirus B, and pancreatic β-cell function, which is crucial in the context of type 1 diabetes (T1D) development and autoimmunity, highlighting direct β-cell killing and impaired T cell responses.
- Carre has developed innovative approaches to antigen discovery in cancer, introducing the MARS method for non-canonical antigen target discovery, indicating a significant advance in immunotherapy and cancer research by unveiling nuanced presentations of MHC-associated peptides.
- A notable aspect of Carre's work is the exploration of immune responses in T1D, including investigations into how interferon-α affects HLA class I peptide presentation in β-cells and how various epitope modifications, like citrullination, may influence T-cell recognition, potentially affecting disease progression.
