Publications by authors named "Alexi Grom"
Background: The American College of Rheumatology (ACR)/Childhood Arthritis and Rheumatology Research Alliance (CARRA) Mentoring Interest Group (AMIGO) is an inter-institutional mentorship program launched to target mentorship gaps within pediatric rheumatology. Initial program evaluation indicated increased mentorship access. Given the small size of the pediatric rheumatology workforce, maintaining a consistent supply of mentors was a potential threat to the longevity of the network.
View Article and Find Full Text PDFBackground: The American College of Rheumatology (ACR)/Childhood Arthritis and Rheumatology Research Alliance (CARRA) Mentoring Interest Group (AMIGO) is an inter-institutional mentorship program launched to target mentorship gaps within pediatric rheumatology. Initial program evaluation indicated increased mentorship access. Given the small size of the pediatric rheumatology workforce, maintaining a consistent supply of mentors was a potential threat to the longevity of the network.
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on a newly identified autoinflammatory disease caused by mutations in a tRNA processing enzyme, particularly examining its clinical features, immune responses, and molecular mechanisms.
- In nine patients diagnosed with congenital sideroblastic anemia, significant genetic mutations were found, along with elevated inflammatory cytokines and notable cellular abnormalities.
- Treatment with a TNF inhibitor successfully reduced inflammation and improved patient outcomes, highlighting the importance of early molecular diagnosis for effective intervention.
Relationship of cell-free urine MicroRNA with lupus nephritis in children.
Pediatr Rheumatol Online J
January 2016
Background: MicroRNAs (miRNAs) are involved in the post-transcriptional regulation of genes. The objective of this study was to investigate whether select urinary cell-free microRNA's may serve as biomarkers in children with active lupus nephritis (LN) and to assess their relationship to the recently identified combinatorial urine biomarkers, a.k.
View Article and Find Full Text PDFBackground: The management of background corticosteroid therapy in rheumatology clinical trials poses a major challenge. We describe the consensus methodology used to design an algorithm to standardize changes in corticosteroid dosing during the Randomized Placebo Phase Study of Rilonacept in Systemic Juvenile Idiopathic Arthritis Trial (RAPPORT).
Methods: The 20 RAPPORT site principal investigators (PIs) and 4 topic specialists constituted an expert panel that participated in the consensus process.
Suppurative peripheral arthritis in inflammatory bowel disease.
J Pediatr Gastroenterol Nutr
July 2007