Publications by authors named "Alexey Slavkov Savov"
Study Design: A case-control study was performed on 105 patients with idiopathic scoliosis (IS) and 210 unrelated gender-matched controls from Bulgarian population.
Objective: Investigation of the association between common genetic polymorphisms of IL-6 and MMP3 genes and the etiology and progression of IS among Bulgarian patients.
Summary Of Background Data: The IL-6 and MMP3 genes have been considered as candidate genes of IS in Caucasian population.
Article Synopsis
- Idiopathic scoliosis (IS) is a complex genetic disorder of the spine, with unknown causes, that involves three-dimensional rotations.
- Researchers studied three specific genetic variations (polymorphisms) in the Bulgarian population to see if they linked to IS susceptibility and progression.
- The study found no significant relationship between these genetic variants and IS in the patients, suggesting that further research is needed in other populations to identify potential molecular markers for better early detection and treatment options.
Idiopathic scoliosis (IS) is the most common spinal disorder in children and adolescents. The current consensus on IS maintains that it has a multifactorial etiology with genetic predisposition factors. In the present study the association of two functional polymorphisms of leptin (rs7799039) and BMP4 (rs4898820) with susceptibility to IS and curve severity was investigated in a Bulgarian population sample.
View Article and Find Full Text PDFBackground: Epidermal growth factor receptor (EGFR) gene mutations are recurrently observed in non-small cell lung carcinomas (NSCLCs), and it has been found that they may serve as specific therapeutic targets. The aim of the present study was to determine the prevalence of EGFR gene mutations in NSCLCs in an East European (Bulgarian) population in different histological subtypes, in cytological versus histological samples and in primary versus metastatic lesions.
Methods: In this study 1427 NSCLC samples were included.