Publications by authors named "Alexey Sazonov"
Risk management has reduced vulnerability to floods and droughts globally, yet their impacts are still increasing. An improved understanding of the causes of changing impacts is therefore needed, but has been hampered by a lack of empirical data. On the basis of a global dataset of 45 pairs of events that occurred within the same area, we show that risk management generally reduces the impacts of floods and droughts but faces difficulties in reducing the impacts of unprecedented events of a magnitude not previously experienced.
View Article and Find Full Text PDFBackground: A functional interplay between BAs and microbial composition in gut is a well-documented phenomenon. In bile, this phenomenon is far less studied, and with this report, we describe the interactions between the BAs and microbiota in this complex biological matrix. .
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- The study examines how liver fluke infection (Opisthorchis felineus) induces chronic oxidative stress, leading to significant disruptions in the hepatic glutathione system, which is essential for detoxifying harmful reactive oxygen species (ROS).
- Chronic infection results in decreased levels of the protective form of glutathione (GSH), lower GSH/GSSG ratios, and reduced enzyme activities that help manage oxidative damage, ultimately causing hepatocellular harm and liver fibrosis.
- Treatments with N-acetylcysteine (NAC) and l-buthionine-S, R-sulfoxinine (BSO) can modify glutathione levels in infected livers, influencing collagen content and fibrosis severity, highlighting the glutath
Article Synopsis
- The European liver fluke, Opisthorchis felineus, causes serious health issues like opisthorchiasis and bile duct cancer, particularly in certain regions of Europe and Central Asia, often going unnoticed due to a lack of specific symptoms.
- Researchers utilized in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) to assess liver damage caused by O. felineus in experimental animals, finding distinctive MR patterns and correlations with histological and biochemical liver data.
- MRI emerges as a promising non-invasive diagnostic tool for evaluating liver impairment and metabolic changes related to O. felineus infection, potentially improving the detection and understanding of liver fibrosis without the complications of liver biopsy.
Article Synopsis
- Liver fluke infection can severely damage the liver but is often overlooked due to unclear symptoms; nanoparticle-enhanced MRI could help detect related liver lesions effectively.
- Researchers modified iron oxide nanoparticles using 3-aminopropylsilane (APS) and analyzed their properties through various techniques to confirm structural integrity and enhance their magnetic capabilities for imaging.
- The study found that these APS-modified nanoparticles can be used as a contrast agent in MRI, showing promising results for diagnosing liver damage caused by liver flukes with minimal toxicity to cells.
Objective: Aim was to study the performance of single-photon emission computed tomography (SPECT) with Tc-pyrophosphate (Tc-PYP) in diagnostics of chronic latent inflammation in myocardium of patients with atrial fibrillation (AF).
Methods: The research included 70 patients (the average age of 49.3 ± 10.
Background: There is increasing interest in the microbiome of the hepatobiliary system. This study investigated the influence of infection with the fish-borne liver fluke, Opisthorchis felineus on the biliary microbiome of residents of the Tomsk region of western Siberia.
Methodology/principal Findings: Samples of bile were provided by 56 study participants, half of who were infected with O.
Article Synopsis
- This study investigates hemozoin, a pigment produced by blood-feeding parasites, specifically in the context of Opisthorchis felineus-infected hamsters, where it forms bile duct ectasia.
- Using a combination of histological analysis, MRI, and advanced spectroscopy techniques, the researchers characterized hemozoin crystals and their impact on liver pathology.
- The findings reveal that hemozoin crystals have specific dimensions and may play a role in modifying the immune response during opisthorchiasis, contributing to a better understanding of its diagnostic and therapeutic implications.
Expression of adenosine receptors in monocytes from patients with bronchial asthma.
Biochem Biophys Res Commun
September 2015
Adenosine is generated from adenosine triphosphate, which is released by stressed and damaged cells. Adenosine levels are significantly increased in patients with bronchial asthma (BA) and mediate mast cell degranulation and bronchoconstriction. Over the last decade, increasing evidence has shown that adenosine can modulate the innate immune response during monocytes differentiation towards mature myeloid cells.
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