Delivery system for dexamethasone phosphate based on a Zn-crosslinked polyelectrolyte complex of diethylaminoethyl chitosan and chondroitin sulfate.

Hybrid nano- and microparticles based on metal ion crosslinked biopolymers are promising carriers for the development of drug delivery systems with improved biopharmaceutical properties. In this work, dexamethasone phosphate-containing particles based on chondroitin sulfate and chitosan or diethylaminoethyl chitosan additionally crosslinked with Zn were prepared. Depending on the polycation/polyanion ratio in the system, anionic and cationic polyelectrolyte complexes (PECs) were obtained.

Assessment of heavy metals distribution and environmental risk parameters in bottom sediments of the Pechora River estuary (Arctic Ocean Basin).

The article is devoted to the study of the content of heavy metals in the bottom sediments of the estuary of the Pechora River, which is the largest river in the European Arctic of Russia. In addition to metals, the particle size distribution and physicochemical parameters of river sediments were analyzed, such as the content of carbonates, organics and ash components. Average concentrations of heavy metals in the sediments of the Pechora Delta sediment have been found to be significantly lower than terrestrial values.

Biophysical Characterization and Cytocompatibility of Cellulose Cryogels Reinforced with Chitin Nanowhiskers.

Polysaccharide-based cryogels are promising materials for producing scaffolds in tissue engineering. In this work, we obtained ultralight (0.046-0.