The effect of prolonged spaceflight on cerebrospinal fluid and perivascular spaces of astronauts and cosmonauts.

Long-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments and visual acuity problems known as spaceflight-associated neuro-ocular syndrome (SANS). The clinical relevance of these changes and whether they equally affect crews of different space agencies remain unknown. We used MRI to analyze the alterations occurring in the perivascular spaces (PVS) in NASA and European Space Agency astronauts and Roscosmos cosmonauts after a 6-mo spaceflight on the International Space Station (ISS).

Medical Issues Associated with Winter Survival Training.

During active phases of manned spaceflight there is a possibility of a spacecraft landing at any point traversed by its orbital path on the Earth. Survival training after emergency landing is an important and vital part of pre-mission preparations. In this paper we analyze medical issues associated with winter survival training in marshy and forested terrain.

Alterations of Functional Brain Connectivity After Long-Duration Spaceflight as Revealed by fMRI.

The present study reports alterations of task-based functional brain connectivity in a group of 11 cosmonauts after a long-duration spaceflight, compared to a healthy control group not involved in the space program. To elicit the postural and locomotor sensorimotor mechanisms that are usually most significantly impaired when space travelers return to Earth, a plantar stimulation paradigm was used in a block design fMRI study. The motor control system activated by the plantar stimulation involved the pre-central and post-central gyri, SMA, SII/operculum, and, to a lesser degree, the insular cortex and cerebellum.

One-Year Mission on ISS Is a Step Towards Interplanetary Missions.

Background: in the 1990s Russian cosmonauts performed six long-duration missions on Mir that went from 312 to 438 d. In 2015 a mission on the International Space Station that continued for 340 d, 8 h, and 47 min was successfully accomplished. It was a joint U.