Publications by authors named "Alexey B Danilov"
Article Synopsis
- Small molecule CGRP receptor antagonists, known as gepants, emerged as a potential treatment for migraines between 2004 and 2011, but initial development faced challenges like oral availability and liver toxicity concerns.
- The newer generation of gepants, including ubrogepant and rimegepant, has recently been approved for treating acute migraines, following a 15-year gap in development.
- The chapter reviews the effectiveness, safety, and tolerability of gepants, as well as their limitations and future potential in migraine treatment.
The term neuronutrition has been proposed as part of nutritional neuroscience, studying the effects of various dietary components on behavior and cognition. Other researchers underline that neuronutrition includes the use of various nutrients and diets to prevent and treat neurological disorders. The aim of this narrative review was to explore the current understanding of the term neuronutrition as the key concept for brain health, its potential molecular targets, and perspectives of its nutritional approach to the prevention and treatment of Alzheimer's and Parkinson's diseases, multiple sclerosis, anxiety, depressive disorders, migraine, and chronic pain.
View Article and Find Full Text PDFObjective: In this narrative review, we summarize clinical and experimental data on the effect of light in migraine and discuss future prospects.
Background: Effective nonpharmacological treatment of hypersensitivity to light in migraine is an unmet clinical need. Current management strategies primarily consist of seeking a dark room and avoiding light exposure.
Psychogenic Seizure Imitating Narcolepsy.
Case Rep Neurol
December 2020
Psychogenic or functional neurological disorders (FND) often occur in the practice of a neurologist. Diagnosis of FND usually causes significant difficulties. Among FND, psychogenic non-epileptic seizures (PNES) comprise around 40% cases.
View Article and Find Full Text PDFIntroduction: Tension-type headache (TTH) is the most prevalent primary headache. Every year, about 2-3% of patients with TTH progress to chronic TTH with daily or near-daily headache, warranting preventive treatment. The treatment of chronic TTH is complex and very often associated with significant tolerability issues.
View Article and Find Full Text PDFThe review is devoted to the complex relationship between headache and sleep disorders. The shared neuroanatomical structures of the nervous system involved in pain perception and sleep are shown, and mechanisms of comorbidity between headaches and sleep disorders are considered. Various types of headaches in the continuum of the sleep-wake cycle are described.
View Article and Find Full Text PDFUnlabelled: Cognitive impairment has been described in all phases of a migraine attack and interictally. However, the prevalence and phenotype of such impairment in chronic migraine (CM) have not yet been studied.
Objectives: The aim of this study was to evaluate both the prevalence of the objective cognitive deficit in patients with CM and the factors underlying its etiology.
Background: The objective of this pilot study was to assess iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) status (hair, serum, and urine) and speciation (serum) in Parkinson's disease (PD) patients.
Methods: A pilot study involving a total of 27 subjects (13 PD patients, 14 controls) was performed. Serum, urine, and hair metal content was assessed using ICP-MS.