Multilevel Analysis of the Influence of Maternal Smoking and Alcohol Consumption on the Facial Shape of English Adolescents.

This cross-sectional study aims to assess the influence of maternal smoking and alcohol consumption during pregnancy on the facial shape of non-syndromic English adolescents and demonstrate the potential benefits of using multilevel principal component analysis (mPCA). A cohort of 3755 non-syndromic 15-year-olds from the Avon Longitudinal Study of Parents and Children (ALSPAC), England, were included. Maternal smoking and alcohol consumption during the 1st and 2nd trimesters of pregnancy were determined via questionnaire at 18 weeks gestation.

Exploring the midline soft tissue surface changes from 12 to 15 years of age in three distinct country population cohorts.

Introduction: Several studies have highlighted differences in the facial features in a White European population. Genetics appear to have a major influence on normal facial variation, and environmental factors are likely to have minor influences on face shape directly or through epigenetic mechanisms.

Aim: The aim of this longitudinal cohort study is to determine the rate of change in midline facial landmarks in three distinct homogenous population groups (Finnish, Latvian, and Welsh) from 12.

What's in a Smile? Initial Analyses of Dynamic Changes in Facial Shape and Appearance.

Single-level principal component analysis (PCA) and multi-level PCA (mPCA) methods are applied here to a set of (2D frontal) facial images from a group of 80 Finnish subjects (34 male; 46 female) with two different facial expressions (smiling and neutral) per subject. Inspection of eigenvalues gives insight into the importance of different factors affecting shapes, including: biological sex, facial expression (neutral versus smiling), and all other variations. Biological sex and facial expression are shown to be reflected in those components at appropriate levels of the mPCA model.

Spatially Dense 3D Facial Heritability and Modules of Co-heritability in a Father-Offspring Design.

The human face is a complex trait displaying a strong genetic component as illustrated by various studies on facial heritability. Most of these start from sparse descriptions of facial shape using a limited set of landmarks. Subsequently, facial features are preselected as univariate measurements or principal components and the heritability is estimated for each of these features separately.

Genetic and Environmental Contributions to Facial Morphological Variation: A 3D Population-Based Twin Study.

Introduction: Facial phenotype is influenced by genes and environment; however, little is known about their relative contributions to normal facial morphology. The aim of this study was to assess the relative genetic and environmental contributions to facial morphological variation using a three-dimensional (3D) population-based approach and the classical twin study design.

Materials And Methods: 3D facial images of 1380 female twins from the TwinsUK Registry database were used.

The influence of snoring, mouth breathing and apnoea on facial morphology in late childhood: a three-dimensional study.

Objective: To explore the relationship between the prevalence of sleep disordered breathing (SDB) and face shape morphology in a large cohort of 15-year-old children.

Design: Observational longitudinal cohort study

Setting: Avon Longitudinal Study of Parents and Children (ALSPAC), South West of England.

Participants: Three-dimensional surface laser scans were taken for 4784 white British children from the ALSPAC during a follow-up clinic.

A three-dimensional analysis of the effect of atopy on face shape.

Three-dimensional (3D) imaging technology has been widely used to analyse facial morphology and has revealed an influence of some medical conditions on craniofacial growth and morphology. The aim of the study is to investigate whether craniofacial morphology is different in atopic Caucasian children compared with controls. Study design included observational longitudinal cohort study.

Facial fluctuating asymmetry is not associated with childhood ill-health in a large British cohort study.

The idea that symmetry in facial traits is associated with attractiveness because it reliably indicates good physiological health, particularly to potential sexual partners, has generated an extensive literature on the evolution of human mate choice. However, large-scale tests of this hypothesis using direct or longitudinal assessments of physiological health are lacking. Here, we investigate relationships between facial fluctuating asymmetry (FA) and detailed individual health histories in a sample (n = 4732) derived from a large longitudinal study (Avon Longitudinal Study of Parents and Children) in South West England.

The influence of asthma on face shape: a three-dimensional study.

Respiratory activity may have an influence on craniofacial development and interact with genetic and environmental factors. It has been suggested that certain medical conditions such as asthma have an influence on face shape. The aim of the study is to investigate whether facial shape is different in individuals diagnosed as having asthma compared with controls.

A population-based cross-sectional study of the association between facial morphology and cardiometabolic risk factors in adolescence.

Objective: To determine whether facial morphology is associated with fasting insulin, glucose and lipids independent of body mass index (BMI) in adolescents.

Design: Population-based cross-sectional study.

Setting: Avon Longitudinal Study of Parents and Children (ALSPAC), South West of England.

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.

Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption, we performed a population-based genome-wide association study of 'age at first tooth' and 'number of teeth' using 5998 and 6609 individuals, respectively, from the Avon Longitudinal Study of Parents and Children (ALSPAC) and 5403 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966). We tested 2 446 724 SNPs imputed in both studies.

A geometric morphometric approach to the analysis of lip shape during speech: development of a clinical outcome measure.

Objective assessments of lip movement can be beneficial in many disciplines including visual speech recognition, for surgical outcome assessment in patients with cleft lip and for the rehabilitation of patients with facial nerve impairments. The aim of this study was to develop an outcome measure for lip shape during speech using statistical shape analysis techniques. Lip movements during speech were captured from a sample of adult subjects considered as average using a three-dimensional motion capture system.

Facial shape and asymmetry in 5-year-old children with repaired unilateral cleft lip and/or palate: an exploratory study using laser scanning.

To investigate the feasibility of facial laser scanning in pre-school children and to demonstrate landmark-independent three-dimensional (3D) analyses for assessment of facial deformity in 5-year-old children with repaired non-syndromic unilateral cleft lip and/or cleft palate (UCL/P). Faces of twelve 5-year-old children with UCL/P (recruited from university hospitals in Cardiff and Swansea, UK) and 35 age-matched healthy children (recruited from a primary school in Cardiff) were laser scanned. Cleft deformity was assessed by comparing individual faces against the age and gender-matched average face of healthy children.

Genome-wide association study of three-dimensional facial morphology identifies a variant in PAX3 associated with nasion position.

Craniofacial morphology is highly heritable, but little is known about which genetic variants influence normal facial variation in the general population. We aimed to identify genetic variants associated with normal facial variation in a population-based cohort of 15-year-olds from the Avon Longitudinal Study of Parents and Children. 3D high-resolution images were obtained with two laser scanners, these were merged and aligned, and 22 landmarks were identified and their x, y, and z coordinates used to generate 54 3D distances reflecting facial features.

The assessment of facial variation in 4747 British school children.

The aim of this study is to identify key components contributing to facial variation in a large population-based sample of 15.5-year-old children (2514 females and 2233 males). The subjects were recruited from the Avon Longitudinal Study of Parents and Children.

Three-dimensional quantification of facial symmetry in adolescents using laser surface scanning.

Laser scanning is a non-invasive method for three-dimensional assessment of facial morphology and symmetry. The aim of this study was to quantify facial symmetry in healthy adolescents and explore if there is any gender difference. Facial scans of 270 subjects, 123 males and 147 females (aged 15.

Three-dimensional longitudinal assessment of facial symmetry in adolescents.

Recent advances in laser scanning technology provide the opportunity to examine faces in three dimensions. The aim of this prospective clinical study was to explore facial symmetry in healthy growing individuals and determine whether asymmetric changes occur during adolescent growth. Non-invasive laser surface scanning was performed to capture facial images of 60 Caucasian Finnish adolescents (30 males and 30 females, mean 11.

[New perspectives on craniofacial growth].

There are subtle facial differences that make people unique. We can distinguish between individuals of different gender, age, ethnicity, race and face type. Traditionally, orthodontists have approached facial assessment using lateral skull and posterior/anterior radiographs which could be combined to build a three-dimensional assessment.

A comparison of plaster, digital and reconstructed study model accuracy.

Objectives: To evaluate the accuracy and reproducibility of a three-dimensional (3D) optical laser-scanning device to record the surface detail of plaster study models. To determine the accuracy of physical model replicas constructed from the 3D digital files.

Design And Setting: A method comparison study using 30 dental study models held in the Orthodontic Department, School of Dentistry, Cardiff University.

A constitutive model for the periodontal ligament as a compressible transversely isotropic visco-hyperelastic tissue.

This study is devoted to the development of a non-linear anisotropic model for the human periodontal ligament (PDL). A thorough knowledge of the behaviour of the PDL is vital in understanding the mechanics of orthodontic tooth mobility, soft tissue response and proposed treatment plans. There is considerable evidence that the deformation of the PDL is the key factor determining the orthodontic tooth movement.

Reliability of measuring facial morphology with a 3-dimensional laser scanning system.

Introduction: The purpose of this prospective clinical trial was to evaluate the reliability of a 3-dimensional facial scanning technique for the measurement of facial morphology.

Methods: A field study was conducted in 2 comprehensive schools in the South Wales region of the United Kingdom. Forty subjects, mean age 11 years 3 months, were analyzed for soft tissue changes at baseline (T1), within 3 minutes (T2), and 3 days later (T3) by using 2 commercially available Minolta Vivid 900 (Osaka, Japan) laser-scanning devices assembled as a stereo pair.