WITHDRAWN: Special Issue on innovative methods for characterizing evolution and budgets in water - rock systems: A tribute to Tom Bullen and Stepan Shvartsev.

The Publisher regrets that this article is an accidental duplication of an article that has already been published, http://dx.doi.org/10.

[Inhibition of Invasive Properties of Murine Melanoma by Bovine Pancreatic DNase I In Vitro and In Vivo].

After a long pause, the accumulation of data on the involvement of tumor-specific DNA and extracellular DNA in metastasis has again placed enzymes with deoxyribonuclease activity in the focus of the search for antitumor and antimetastatic drugs. In this work, the ability of bovine pancreatic DNase I to reduce the invasive potential of B16 melanoma has been investigated in vitro and in vivo. It was found that DNase I had a cytotoxic effect on B16 melanoma cells (IC50 ≈ 10^(4) U/mL).

Morphological changes in human skin melanoma treated by high-energy pulsed neodymium laser radiation.

Purpose: The neodymium (Nd) laser irradiation has been successfully applied to the treatment of slightly elevated skin melanoma. At the same time the histologic aspects of such a treatment have not been precisely investigated. The aim of this study was to retrace the histological features in human primary cutaneous melanomas after 1060 nm high energy mono pulsed Nd laser treatment in the dynamic healing of the affected tissues.

Inhibitors of Epstein-Barr virus reproduction--ribonucleosides of 3-substituted 1,2,4-triazino[5,6-b] [1,4] benzothiasines.

Studying of antiviral effect of condensed triazine derivatives--3-oxo- triazinobenzothiazine (the preparation No 1), its ribonucleoside (the preparation No 3) and ribonucleoside of its 3-thio-analogue (the preparation No 2) on reproduction of Epstein-Barr virus (EBV) in lymphoblastoid Raji cells is reported in present work. The cytotoxic action of these preparations on test cells was determined and CC50 index was 125 microg/ml for the preparation No 1, for preparation No 2 - 625 microg/ml, and for preparation No 3 - 750 microg/ml. Antiviral activity of the preparations was tested by inhibition level of accumulation of viral DNA in the cell culture, and effective concentration (EC50 index) was determined for each preparation.

Bioaccumulation of PCBs and chlorinated pesticides in seals, fishes and invertebrates from the White Sea, Russia.

Persistent organochlorines (OC) contaminants, including polychlorinated biphenyl (PCB) congeners, Dichlorophenyltrichloroethane (DDT)- and chlordane (CHL) related compounds, hexachlorocyclohexanes (HCH) isomers and chlorobenzenes (CBz) were determined in blubber of harp seals (Phoca groenlandica), ringed seals (Phoca hispida) and bearded seals (Eringnathus barbatus) as well as in fishes and invertebrates from the White Sea, in northwest Russia. Highest summation operator PCB and summation operator DDT concentrations were found in samples from two male bearded seals (means of 4150 ng/g lw and 3950 ng/g lw, respectively). Female harp seals had mean summation operator PCB and summation operator DDT concentrations of 1070+/-504 ng/g lw and 619+/-328 ng/g lw, respectively.

Organochlorine pesticide and trace metal monitoring of Russian rivers flowing to the Arctic Ocean: 1990-1996.

Information is presented on the concentrations of organochlorine pesticides (HCHs and DDT residues) and trace metals (Fe, Cu, Zn and Ni) in waters of 15 large Russian rivers flowing to the Arctic Ocean during 1990-1996. Estimates of the corresponding annual fluxes are made. Other contaminants (Hg, Pb, Cr, Mn, beta-HCH and dihydroheptachlor) were examined briefly.

Contaminants in the Canadian Arctic: 5 years of progress in understanding sources, occurrence and pathways.

Recent studies of contaminants under the Canadian Northern Contaminants Program (NCP) have substantially enhanced our understanding of the pathways by which contaminants enter Canada's Arctic and move through terrestrial and marine ecosystems there. Building on a previous review (Barrie et al., Arctic contaminants: sources, occurrence and pathways.

Prevalence of rheumatoid arthritis in circumpolar native populations.

Objective: To compare the prevalence of rheumatoid arthritis (RA) in related, but geographically separate, indigenous circumpolar populations.

Methods: Cases were identified by community survey in Russia and by examination of cases located through arthritis registries, a computerized patient information database, and query of local health care providers in Alaska. All possible cases were verified by examination and application of the American College of Rheumatology 1987 criteria.

Spondylarthropathic diseases in indigenous circumpolar populations of Russia and Alaska.

Aims: To compare the nature and frequency of spondylarthropathy in geographically separated but genetically related populations with a high prevalence of HLA-B27.

Methods: Using a common questionnaire and disease criteria, cases were ascertained through cross-sectional community surveys in Russia and by examination and study of possible cases identified through rheumatic disease registries and the Native Health Service's computerized patient care data system in Alaska.

Results: Similar overall prevalences of spondyloarthropathy (2.

Spondyloarthropathies in circumpolar populations: II. Characterization of the populations.

For epidemiologic studies of spondyloarthropathy in circumpolar peoples of Chukotka, Russia and Alaska, we gathered demographic, physical and laboratory data to provide a background for evaluating and comparing factors that may influence susceptibility and clinical expression of disease. The study groups included the Chukchi and Siberian Eskimo of Russia and the Inupiat and Yupik Eskimo of Alaska. The 4 groups were remarkably similar in population structure, educational attainment, mean hemoglobin concentrations and frequency of the Class I histocompatibility antigen HLAB27.

Spondyloarthropathies in circumpolar populations: I. Design and methods of United States and Russian studies.

Parallel epidemiologic studies of spondyloarthropathy in aboriginal circumpolar populations were carried out by U.S. and Russian investigators.

HLA class II and HLA-B27 oligotyping in two Siberian native population groups.

It was the purpose of this study to better define the frequency of HLA-B27 subtypes and HLA class II alleles among indigenous populations from the eastern tip of the Chukotka Peninsula of Siberia, Russia, which have higher frequencies of HLA-B27 (40%) and spondyloarthropathies (2%) than Caucasian populations and test the hypothesis that these populations are more closely related to Orientals. Siberian Eskimos and Chukchi residing in four coastal villages on the Chukotka Peninsula inhabited by Siberian Eskimos and Chukchi people were examined using oligotyping of the polymerase-chain reaction-amplified second and third exons of the HLA-B27 gene. HLA-class II alleles (DRB1, DQA1 and DQB1) were similarly determined.

HLA-B27 subtypes among the Chukotka Native groups.

The purpose of this study was to assess the relative frequency of the known HLA-B27 subtypes in HLA-B27 positive Chukotka natives, which have higher frequencies of HLA-B27 (to 40%) and spondyloarthropathies (to 2%) than the Russian Caucasian population. Using oligotyping of the polymerase-chain reaction amplified second and third exons of the HLA-B27 gene in 86 DNA samples from HLA-B27 positive individuals were successfully typed. All had HLA-B*2705, including 4 patients with Reiter's syndrome and 5 with ankylosing spondyloarthritis, except one Eskimo who had HLA-B*2702.

Prevalence of spondyloarthropathies and HLA-B27 in the native population of Chukotka, Russia.

Objective: We sought to determine the prevalence and nature of spondyloarthropathies (SPA) and the prevalence of HLA-B27 in the native selected circumpolar population of Chukotka, Russia.

Methods: We conducted a cross sectional study that included medical examinations and interviews of 355 of 498 (71.3%) native residents of 2 Eastern Chukotka settlements, Enmelen and Nunligran.