Publications by authors named "Alexandru-Bogdan Stache"
6-hydroxy-L-nicotine (6HLN) is a nicotine (NIC) derivative with proven therapeutic potential in neurodegenerative disorders. Here, the impact of 6HLN on cell growth, migratory behavior, and inflammatory status of three different cancer cell lines (A549, MCF7, and U87) and two normal cell lines (16HBE14o and MCF10A) was investigated. In silico analyses were conducted to evaluate the binding affinity of 6HLN to nicotinic receptors (nAChRs) containing α9 and α5 subunits.
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- Growing interest in cognitive dysfunction related to Alzheimer's disease (AD) highlights the need for effective therapies, as current treatments have limitations.
- Flavonoids have shown promise due to their antioxidative, anti-inflammatory, and anti-amyloidogenic properties, which could help combat AD symptoms.
- In this study, researchers tested three flavonoids in zebrafish to assess their potential to improve memory, reduce anxiety, and lower oxidative stress, finding that these compounds positively influence gene expression related to neuroprotection and synaptic function.
Comparative In Vitro Study between Biocompatible Chitosan-Based Magnetic Nanocapsules and Liposome Formulations with Potential Application in Anti-Inflammatory Therapy.
Gabriela Vochița Anca Niculina Cadinoiu Delia-Mihaela Rață Leonard Ionuț Atanase Marcel Popa Alexandru-Bogdan Stache
Int J Mol Sci
August 2024
This study describes the comparison between the interaction of a series of peptide-functionalized chitosan-based nanocapsules and liposomes with two cell lines, i.e., mouse macrophages RAW 264.
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