Publications by authors named "Alexandru Sandor"
Considering the pivotal role of angiogenesis in solid tumor progression, we developed a novel series of quinazoline-thiazole hybrids () as antiproliferative and anti-angiogenic agents. Four out of the seven compounds displayed superior antiproliferative activity (IC =1.83-4.
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- The epidermal growth factor receptor (EGFR) is crucial in cancer development, and targeting its mutant forms has led to three generations of approved inhibitors.
- The quinazoline structure is particularly effective for creating new EGFR inhibitors because it binds well to the active site of the EGFR kinase.
- This review discusses the structural changes that enhance the effectiveness against common and resistant EGFR mutants, and highlights new quinazoline derivatives being developed as potential inhibitors.