Publications by authors named "Alexandru S Barcan"
Background: The development, progression, and dissemination of antimicrobial resistance (AMR) are determined by interlinked human, animal, and environmental drivers, which pose severe risks to human and livestock health. Conjugative plasmid transfer drives the rapid dissemination of AMR among bacteria. In addition to the judicious use and implementation of stewardship programs, mitigating the spread of antibiotic resistance requires an understanding of the dynamics of AMR transfer among microbial communities, as well as the role of various microbial taxa as potential reservoirs that promote long-term AMR persistence.
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- * Factors contributing to AMR include the overuse and misuse of antimicrobials, alongside ancient molecular mechanisms that have evolved in bacteria, showcasing a historic and ongoing battle between bacteria and treatments.
- * Understanding environmental influences and predictive genetic factors of AMR is essential for developing new treatment strategies that could effectively combat resistant bacteria in the future.
Article Synopsis
- * It evaluates both clinical and preclinical studies, detailing significant health benefits such as managing diabetes, neurodegenerative disorders, and cancer.
- * The findings suggest that these fungal polysaccharides can substantially alter gut microbiota composition, potentially mediating their therapeutic effects and highlighting a promising area for future research.