The Impact of HIV on Early Brain Aging-A Pathophysiological (Re)View.

: This review aims to provide a comprehensive understanding of how HIV alters normal aging trajectories in the brain, presenting the HIV-related molecular mechanisms and pathophysiological pathways involved in brain aging. The review explores the roles of inflammation, oxidative stress, and viral persistence in the brain, highlighting how these factors contribute to neuronal damage and cognitive impairment and accelerate normal brain aging. Additionally, it also addresses the impact of antiretroviral therapy on brain aging and the biological markers associated with its occurrence.

Clinical Acceptance of Digitally Produced Zirconia and Metal Post and Cores, Based on the Impression Method.

Background: The existing literature predominantly examines post and core assessments post-cementation, neglecting the critical pre-cementation phase. Research on the clinical acceptance of dental posts received from dental laboratories before cementation is notably lacking. This study investigates the percentage of zirconia and metal dental posts that are deemed suitable for cementation by clinicians, among the total received from the dental laboratory.

Horizontal ridge augmentation through ridge expansion via osseodensification, guided bone regeneration and ridge‑split: Systematic review and meta‑analysis of clinical trials.

The aim of the present systematic review was to compare three ridge augmentation procedures in order to assist clinicians in finding the ideal surgical method relative to the horizontal bone gain needed and the width of the alveolar ridge available. An electronic and hand literature search was performed in the online databases PubMed-Medline, Cochrane Central Register of Controlled Trials, EMBASE, Cochrane Oral Health Group Trials Register and Web of Science, and various specialized journals, between January 2017 and December 2022. The included studies were evaluated using the Methodological Index for Non-randomized Studies score and Cochrane's RoB tool.

Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors.

Protein prenylation is one example of a broad class of post-translational modifications where proteins are covalently linked to various hydrophobic moieties. To globally identify and monitor levels of all prenylated proteins in a cell simultaneously, our laboratory and others have developed chemical proteomic approaches that rely on the metabolic incorporation of isoprenoid analogues bearing bio-orthogonal functionality followed by enrichment and subsequent quantitative proteomic analysis. Here, several improvements in the synthesis of the alkyne-containing isoprenoid analogue C15AlkOPP are reported to improve synthetic efficiency.

The Role of Cytokines and Molecular Pathways in Lung Fibrosis Following SARS-CoV-2 Infection: A Physiopathologic (Re)view.

SARS-CoV-2 infection is a significant health concern that needs to be addressed not only during the initial phase of infection but also after hospitalization. This is the consequence of the various pathologies associated with long COVID-19, which are still being studied and researched. Lung fibrosis is an important complication after COVID-19, found in up to 71% of patients after discharge.

Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1.

Protein lipidation is a post-translational modification that confers hydrophobicity on protein substrates to control their cellular localization, mediate protein trafficking, and regulate protein function. In particular, protein prenylation is a C-terminal modification on proteins bearing canonical motifs catalyzed by prenyltransferases. Prenylated proteins have been of interest due to their numerous associations with various diseases.

Sequencing and Partial Molecular Characterization of BAB-TMP, the Babeș Strain of the Fixed Rabies Virus Adapted for Multiplication in Cell Lines.

The rabies virus is a major zoonosis that causes severe nervous disease in humans, leading to paralysis and death. The world's second anti-rabies center was established in 1888 by Victor Babeș, in Bucharest, where an eponymous strain of rabies was isolated and used to develop a method for immunization. The Babeș strain of the rabies virus was used for over 100 years in Romania to produce a rabies vaccine for human use, based on animal nerve tissue, thus having a proven history of prophylactic use.

The portrait of a stranger: the hypereosinophilic syndrome with cardiac involvement.

Introduction: Hypereosinophilic syndrome is a rare clinical condition, and cardiac involvement confers a poor prognosis. Hypereosinophilic myocarditis is a medical emergency and targeted treatment should be started promptly even before a definitive diagnosis could be made.

Case Presentation: A 27-year-old female patient is hospitalized for exertional dyspnea, chest pain, and fatigue for the past 2 weeks.

Methods of postural analysis in connection with the stomatognathic system. A systematic review.

This systematic review aimed to identify the main tools used to analyze the relationship between the postural and stomatognathic systems. The study followed the PRISMA guidelines, and data were collected from Science Direct and PubMed databases to identify articles published until December 2022. After applying inclusion and exclusion criteria, 26 articles were selected from the initial 903 articles.

A new technique to transfer the upper maxillary arch position using a facebow, a transfer table, and a reference block with a CAD application.

This paper presents a method for the digital transfer of the upper maxillary arch position using a facebow, a transfer table, and a reference block with a CAD application without requiring physical casts mounted with articulating gypsum. This technique facilitates the prosthetic digital workflow when the impression is made via intraoral scanning, to obtain the placement of the maxillary arch in the anatomical reference planes and in relation to the axes of rotation of the mandibular movements.

Biosynthesis and Bioapplications of Nanomaterials from Mushroom Products.

The production of nanoparticles (NPs) from chemical and physical synthesis has ended due to the involvement of toxic byproducts and harsh analytical conditions. Innovation and research in nanoparticle synthesis are derived from biomaterials that have gained attention due to their novel features, such as ease of synthesis, low-cost, eco-friendly approach, and high water solubility. Nanoparticles obtained through macrofungi involve several mushroom species, i.

Fully digital workflow for retrofitting a new crown to an existing removable partial denture.

A fully digital technique for retrofitting a new crown to a removable partial denture (RPD) is presented. The conventional crown preparation was followed by intraoral scanning of the preparation, the antagonists, and the occlusal relationship and by scanning the RPD both in situ and outside the oral cavity. All the standard tessellation language (STL) files were indexed in a design software program, and the new crown was designed.

Modular Digital and 3D-Printed Dental Models with Applicability in Dental Education.

: The ever more complex modern dental education requires permanent adaptation to expanding medical knowledge and new advancements in digital technologies as well as intensification of interdisciplinary collaboration. Our study presents a newly developed computerized method allowing virtual case simulation on modular digital dental models and 3D-printing of the obtained digital models; additionally, undergraduate dental students' opinion on the advanced method is investigated in this paper. : Based on the digitalization of didactic dental models, the proposed method generates modular digital dental models that can be easily converted into different types of partial edentulism scenarios, thus allowing the development of a digital library.

Compressive and Flexural Strength of 3D-Printed and Conventional Resins Designated for Interim Fixed Dental Prostheses: An In Vitro Comparison.

A provisionalization sequence is essential for obtaining a predictable final prosthetic outcome. An assessment of the mechanical behavior of interim prosthetic materials could orient clinicians towards selecting an appropriate material for each clinical case. The aim of this study was to comparatively evaluate the mechanical behavior-with compressive and three-point flexural tests-of certain 3D-printed and conventional resins used to obtain interim fixed dental prostheses.

Biochemical Interaction between Materials Used for Interim Prosthetic Restorations and Saliva.

The purpose of this study was to analyze the oxidative stress level and inflammatory status of saliva in the presence of certain materials used for obtaining interim prosthetic restorations. Four types of interim resin materials were investigated: a pressure/heat-cured acrylic resin (Superpont C+B, SpofaDental a.s Czech Republic, /KaVo Kerr Group), a milled resin (Telio CAD polymethyl methacrylate, Ivoclar Vivadent AG, Liechtenstein), a 3D printed resin (NextDent C&B MFH, NextDent by 3D Systems, the Netherlands), and a pressure/heat-cured micro-filled indirect composite resin (SR Chromasit, Ivoclar Vivadent AG, Liechtenstein).

Biologic and Esthetic Outcome of CAD/CAM Custom Ceramic Implant Abutment: A Clinical Report.

A prerequisite of a functional and esthetical implant-supported crown is a proper surgical planning and an abutment with a design and color that maintain the initial soft-tissue contour. This clinical report describes the use of a custom ceramic implant abutment designed with computer-aided design and computer-aided manufacturing (CAD/CAM) technology. A zirconia framework was milled and cemented extra orally to a prefabricated titanium base, the new custom abutment being both precise and esthetic.

A cascade reaction of cinnamyl azides with vinyl sulfones directly generates dihydro-pyrrolo-pyrazole heterocycles.

This report describes the direct synthesis of dihydro-pyrrolo-pyrazole heterocycles from allylic azides and methyl vinyl sulfone. The product results from a complex cascade reaction that is operationally straightforward, with aromatization being the result of a concomitant elimination step. A variety of azides could participate in this reaction (12 examples) and the isolated yields of the desired product ranged from 51%-72%.

A novel experimental approach to evaluate guided bone regeneration (GBR) in the rat femur using a 3D-printed CAD/CAM zirconia space-maintaining barrier.

Introduction: Obtaining a certain bone volume is an important goal in implantology or orthopedics. Thus, after tooth extraction, quite a lot of horizontal and vertical alveolar bone is lost in time and can be detrimental to the implant treatment outcome, while the treatment of critical bone defects is a considerable challenge for surgery.

Objectives: In this study we designed a new in vivo model as an useful experimental tool to assess guided bone regeneration (GBR) using a computer-aided design/manufacturing (CAD-CAM) space-maintaining barrier.

Elderly Patients' Perception of Previewing the Prosthetic Treatment Outcome.

The demographic statistics indicate that, with the industrial development and the advances in the medical field, the average life of the population has started to increase significantly; consequently, the needs of treatments in geriatric dentistry are becoming more and more significant. The purpose of this study was to evaluate patients' perception of diverse techniques used to obtain previews for final fixed prosthetic restorations: digital smile design (DSD), wax-up, indirect mock-up, temporary restorations, Computer-Aided Design (CAD). A focus group that included 11 participants, all of them geriatric patients, was formed; patients were invited to respond to a set of seven questions before and after various previsualization methods were applied.

Evidence of Connections Between Periodontitis and Ischemic Cardiac Disease - an Updated Systematic Review.

The association between chronic periodontitis and cardiovascular disease is still controversial, despite the plethora of research on this topic. The objective of this systematic review is to update the level of evidence on connection between periodontal and cardiovascular disease. The review question is: could a link between periodontal disease and ischemic cardiac disease be established? A PubMed, Science Direct and Scopus systematic search was performed, which was restricted only to articles published in English or French during the last five years.

Virtual facebow technique using standardized background images.

The procedure described provides a novel and accessible virtual facebow transfer based on standardized photographs loaded in the virtual articulator module of a computer-assisted design and computer-assisted manufacturing (CAD-CAM) software program for dental applications. The practical application of the technique in a digital workflow is the correct alignment of the digital maxillary cast to the virtual articulator with respect to the patient's planes and the skin markings of the condylar axis.

Osteotome-mediated sinus floor elevation: a systematic review and meta-analysis.

Purpose: The objectives of this study were to systematically review the literature regarding sinus floor elevation using osteotomes with respect to the timing of implant placement, implant characteristics, grafting materials, and intraoperative and postoperative complications and to perform a meta-analysis to determine the influence of initial residual bone height (RBH) on implant success.

Materials And Methods: A systematic search of articles was conducted on MEDLINE and manually to identify studies of sinus floor elevation using osteotomes. Strict inclusion criteria were applied.