Publications by authors named "Alexandros S Pollatos"
Article Synopsis
- The text discusses the first successful total synthesis of dragocins A-C, which are unique natural products with a distinctive C4' oxidized ribose structure connected by a polyhydroxylated pyrrolidine.
- The synthesis process involved several complex steps, including a notable failure when trying to perform a C-H oxidation on an important intermediate.
- The final synthesis method included an efficient approach for creating a complex pyrrolidine and a novel selective electrochemical oxidation that produced a characteristic 9-membered ring, suggesting this technique could be broadly applicable in future research.
Dehydrohalogenation, or elimination of hydrogen-halide equivalents, remains one of the simplest methods for the installation of the biologically-important olefin functionality. However, this transformation often requires harsh, strongly-basic conditions, rare noble metals, or both, limiting its applicability in the synthesis of complex molecules. Nature has pursued a complementary approach in the novel vitamin B-dependent photoreceptor CarH, where photolysis of a cobalt-carbon bond leads to selective olefin formation under mild, physiologically-relevant conditions.
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