Publications by authors named "Alexandros Anninos"
Article Synopsis
- Cardiovascular disease is a major health concern for children with chronic kidney disease (CKD), with gut-derived toxins increasing as kidney function worsens, affecting heart health.
- The study measured levels of indoxyl sulfate (IS) and p-cresyl sulfate (pCS) in children's blood and examined their relationship with vascular health indicators, such as carotid thickness and pulse wave velocity.
- Results showed that higher serum levels of these toxins were linked to decreased kidney function, and only indoxyl sulfate (IS) was meaningfully associated with cardiovascular disease markers over time in the CKD pediatric population.
Biochemical detection of inborn errors of creatine metabolism or transport relies on the analysis of three main metabolites in biological fluids: guanidinoacetate (GAA), creatine (CT) and creatinine (CTN). Unspecific clinical presentation of the diseases might be the cause that only few patients have been diagnosed so far. We describe a LC-MS/MS method allowing fast and reliable diagnosis by simultaneous quantification of GAA, CT and CTN in urine, plasma and cerebrospinal fluid (CSF) and established reference values for each material.
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