Publications by authors named "Alexandrine Larouche"

Article Synopsis
  • The study focused on understanding patient-ventilator asynchrony in critically ill children, highlighting significant issues with ventilator interactions and identifying key risk factors.
  • Approximately 52 children were monitored, revealing that more than a quarter of their time on the ventilator was marked by asynchrony, which was mainly due to cycling-off errors and trigger delays.
  • Despite documenting high levels of asynchrony, there was no clear link found between the severity of asynchrony and improved outcomes like ventilator-free days, indicating a need for better strategies in pediatric critical care.
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Background: Infants have to actively maintain their end expiratory lung volume (EELV). In mechanically ventilated infants, the diaphragm stays activated until the end of expiration (tonic activity), contributing to EELV maintenance. It is unclear whether tonic activity compensates for the lack of laryngeal braking due to intubation or if it is normally present.

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Purpose: Diaphragm function should be monitored in critically ill patients, as full ventilatory support rapidly induces diaphragm atrophy. Monitoring the electrical activity of the diaphragm (EAdi) may help assess the level of diaphragm activity, but such monitoring results are difficult to interpret because reference values are lacking. The aim of this study was to describe EAdi values in critically ill children during a stay in the pediatric intensive care unit (PICU), from the acute to recovery phases, and to assess the impact of ventilatory support on EAdi.

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