Ketoprofen Associated with Hyaluronic Acid Hydrogel for Temporomandibular Disorder Treatment: An In Vitro Study.

Temporomandibular disorders (TMD) are a public health problem that affects around 12% of the global population. The treatment is based on analgesics, non-steroidal anti-inflammatory, corticosteroids, anticonvulsants, or arthrocentesis associated with hyaluronic acid-based viscosupplementation. However, the use of hyaluronic acid alone in viscosupplementation does not seem to be enough to regulate the intra-articular inflammatory process.

Development of PHBV electrospun fibers containing a borate bioactive glass doped with Co, Cu, and Zn for wound dressings.

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers embedded with borate glasses of 45B5 composition doped with Co, Cu, and Zn (46.1 B₂O₃26.9-X CaO24.

Strontium-Doped Bioglass-Laden Gelatin Methacryloyl Hydrogels for Vital Pulp Therapy.

This study aimed to develop gelatin methacryloyl (GelMA)-injectable hydrogels incorporated with 58S bioactive glass/BG-doped with strontium for vital pulp therapy applications. GelMA hydrogels containing 0% (control), 5%, 10%, and 20% BG (/) were prepared. Their morphological and chemical properties were evaluated by scanning electron microscopy/SEM, energy dispersive spectroscopy/EDS, and Fourier transform infrared spectroscopy/FTIR (n = 3).

Gellan-Based Hydrogel as a Drug Delivery System for Caffeic Acid Phenethyl Ester in the Treatment of Oral Infections.

can cause various types of oral infections, mainly associated with denture stomatitis. Conventional therapy has been linked to high recurrence, toxicity, and fungal resistance, necessitating the search for new drugs and delivery systems. In this study, caffeic acid phenethyl ester (CAPE) and gellan gum (GG) were studied as an antifungal agent and carrier system, respectively.

Enhancing mouthguard longevity: Impact of surface treatment against aging from brushing and disinfectant exposure.

Background/aims: The study aimed to assess the surface characteristics of sports mouthguards under mechanical stresses during cleaning, either by brushing or immersion in disinfectant solutions.

Material And Methods: Ethylene-vinyl acetate samples, 4 mm thick, were randomly assigned to cleaning methods: control (C-no cleaning), brushing with water (B.W), brushing with neutral liquid soap (B.

Chlorinated-based bioceramics incorporated in polycaprolactone membranes.

The development of bioactive membranes with bone repair properties is great interest in the field of tissue engineering. In this study, we aimed to fabricate and characterize a composite membrane composed of sol-gel synthesized bioceramics and electrospun polycaprolactone (PCL) fibers for bone tissue regeneration applications. The bioceramics were prepared using the sol-gel method with nitrate (N) and chloride (CL) as precursors.

Fatigue behavior, failure mode, and stress distribution of occlusal veneers: influence of the prosthetic preparation cusp inclinations and the type of restorative material.

Objective: To evaluate the effects of cusp inclination of the prosthetic preparation's occlusal surface and type of restorative material on the fatigue behavior, failure mode, and stress distribution of occlusal veneers.

Materials And Methods: Glass fiber-reinforced epoxy resin prosthetic preparations for occlusal veneers with three different occlusal surface cusp inclination degrees (0°, 15°, and 30°) were produced and assigned into six testing groups (n = 11) according to the cusp inclination (0°, 15°, or 30°) and type of restorative material (lithium disilicate-LD or resin composite-RC). Despite different substrate preparation cusp inclination degrees, the restorations were designed maintaining 30° inclination between the cusps at the occlusal surface and a thickness of 0.

Carbon fiber: Characterization and evaluation of the inflammatory response and toxicity in rats.

This study aimed to evaluate the Carbon Fiber obtained from PAN textile and cotton fiber in their different forms of presentation: non-activated carbon fiber felt (NACFF), activated carbon fiber felt (ACFF), silver activated carbon fiber felt (Ag-ACFF), and activated carbon fiber tissue (ACFT), to obtain scaffolds as a potential material with properties related to the synthetic bone graft. Characterization tests performed: surface wettability, traction, swelling, and in vivo tests: evaluation of the inflammatory response by implanting the materials in the subcutaneous tissue of 14 Wistar rats, evaluation of collagen fibers by picrosirius red staining and assessment of toxicity in the following organs: heart, spleen, liver, and kidney. In the wettability test, NACFF and ACFT were hydrophobic (θ124° and 114°), ACFF and Ag-ACFF were hydrophilic.

Fatigue resistance of polymeric restorative materials: effect of supporting substrate.

The objective of this study was to investigate the effect of mismatch between the elastic properties of substrate and restorative material on the fatigue resistance and stress distribution of multilayer structures. The tested hypotheses were that (1) both an indirect composite resin (IR) and a polymer-infiltrated ceramic network (PICN) would show a higher survival rate after cyclic loading when cemented to a substrate with a high elastic modulus (E); and (2) PICN structures would have higher survival rates than IR structures regardless of the supporting substrate. Blocks of PICN and IR were cut to obtain 1.

How does the occlusal contact region influence the mechanical fatigue performance and fracture region of monolithic lithium disilicate ceramic crowns?

Objective: To characterize the effect of the occlusal contact region on the mechanical fatigue performance and on the fracture region of monolithic lithium disilicate ceramic crowns.

Materials And Methods: Monolithic lithium disilicate ceramic crowns were machined in a CAD/CAM system and adhesively luted onto glass-fiber reinforced epoxy resin preparations with resin cement. The crowns were divided into three groups (n = 16) according to load application region (cusp tip: restricted to cusp tips; cusp plane: restricted to cuspal inclined plane; or mixed: associating tip cusp and cuspal inclined plane).

Fluoride and Calcium Release from Alkasite and Glass Ionomer Restorative Dental Materials: In Vitro Study.

This study evaluated the effect of pH and temperature on the ion (F and Ca) release of a resin-based material containing alkaline fillers and a self-setting high-viscous glass ionomer cement. Disks were prepared according to manufacturers' instructions for both materials: the EF group (Equia Forte HT filling, GC) and the CN group (, Ivoclar). Specimens were immersed in 50 mL buffer solution with three different pHs (4.

Effect of resin cement elastic modulus on the biaxial flexural strength and structural reliability of an ultra-thin lithium disilicate glass-ceramic material.

Objectives: Photo- and dual-polymerized resin-based luting agent was evaluated for elastic moduli effects on ultra-thin lithium disilicate (LD) glass-ceramic strengthening, structural reliability, and stress distribution.

Materials And Methods: One hundred-sixty LD discs (IPS e.max CAD, Ivoclar/Vivadent) were produced in ultra-thin thicknesses (half with 0.

Substrate Rigidity Effect on CAD/CAM Restorations at Different Thicknesses.

Objectives:  This article evaluated the effect of substrates rigidities on the post-fatigue fracture resistance of adhesively cemented simplified restorations in lithium disilicate glass ceramic.

Methods:  Precrystalized computer-aided design/computer-aided manufacturing ceramic blocks were processed into disc-shaped specimens ( = 10,  = 10 mm), mimicking a simplified restoration at two thicknesses (0.5 and 1.

Bioengineering Tools Applied to Dentistry: Validation Methods for In Vitro and In Silico Analysis.

This study aimed to evaluate the use of bioengineering tools, finite element analysis, strain gauge analysis, photoelastic analysis, and digital image correlation, in computational studies with greater validity and reproducibility. A bibliographic search was performed in the main health databases PUBMED and Scholar Google, in which different studies, among them, laboratory studies, case reports, systematic reviews, and literature reviews, which were developed in living individuals, were included. Therefore, articles that did not deal with the use of finite element analysis, strain gauge analysis, photoelastic analysis, and digital image correlation were excluded, as well as their use in computational studies with greater validity and reproducibility.

Effects of material and piston diameter on the fatigue behavior, failure mode, and stress distribution of feldspathic ceramic simplified restorations.

This study evaluated the influence of the piston material (glass fiber-reinforced epoxy resin or stainless steel) and the piston tip diameter (6 or 40 mm) on the fatigue mechanical behavior, failure mode, and stress distribution of feldspathic ceramic simplified restorations. Pistons were machined in glass fiber-reinforced epoxy resin (ER) and in stainless steel (SS), with active tips simulating the curvature radius of 6- or 40-mm diameter spheres. A total of sixty (N= 60) feldspathic ceramic discs (Ø= 10 mm; thickness= 1.

Electrospun polylactic acid scaffolds with strontium- and cobalt-doped bioglass for potential use in bone tissue engineering applications.

The development of nanoscale biomaterials associated with polymers has been growing over the years, due to their important structural characteristics for applications in biological systems. The present study aimed to produce and test polymeric scaffolds composed of polylactic acid (PLA) fibers associated with a 58S bioglass doped with therapeutic ions for use in tissue engineering. Three 58S Bioglass was obtained by the sol-gel route, pure and doped with 5% strontium and cobalt ions.

Polycaprolactone/chlorinated bioglass scaffolds doped with Mg and Li ions: Morphological, physicochemical, and biological analysis.

The objective was to synthesize and characterize fine polycaprolactone (PCL) fibers associated with a new 58S bioglass obtained by the precipitated sol-gel route, produced by the electrospinning process in order to incorporate therapeutic ions (Mg and Li). In PCL/acetone solutions were added 7% pure bioglass, bioglass doped with Mg(NO ) and Li CO and were subjected to electrospinning process. The fibers obtained were characterized morphologically, chemically and biologically.

Impact of different complete coverage onlay preparation designs and the intraoral scanner on the accuracy of digital scans.

Statement Of Problem: The trueness and precision of intraoral scanners (IOSs) and the effect of intracoronal restorations have been reported. However, studies addressing the accuracy of IOSs in reproducing different complete coverage onlay preparation designs are lacking.

Purpose: The purpose of this in vitro study was to evaluate the influence of complete coverage onlay preparation design and intraoral scanning devices on the accuracy of digital scans in terms of trueness and precision.

Fracture resistance and biomechanical behavior of different access cavities of maxillary central incisors restored with different composite resins.

Objectives: The aim of this study was to compare the effect of three different access cavities on the tissue removal, deflection, fracture resistance, and stress distribution of extracted maxillary central incisors.

Materials And Methods: Forty human maxillary central incisors were randomly assigned in four experimental group (n = 10) including conservative access cavity "CAC," traditional access cavity "TAC," invasive access cavity "IAC," and without access cavity (control group). Cone-beam computed tomography "CBCT" scans were used to evaluate the tissue removal during the different access cavities.

Canine guidance reconstruction with ceramic or composite resin: A 3D finite element analysis and in vitro wear study.

Statement Of Problem: Wear of the maxillary canine cusps is a common clinical condition which can affect function and esthetics and, in some situations, lead to occlusal pathology. The mechanical behavior of different restorative techniques for the condition is unclear.

Purpose: The purpose of this in vitro study was to evaluate the biomechanical behavior of direct or indirect restorative techniques used in restoring canine guidance.

Influence of Framework Material and Posterior Implant Angulation in Full-Arch All-on-4 Implant-Supported Prosthesis Stress Concentration.

This study evaluated the influence of distal implants angulation and framework material in the stress concentration of an All-on-4 full-arch prosthesis. A full-arch implant-supported prosthesis 3D model was created with different distal implant angulations and cantilever arms (30° with 10-mm cantilever; 45° with 10-mm cantilever and 45° with 6-mm cantilever) and framework materials (Cobalt-chrome [CoCr alloy], Yttria-stabilized tetragonal zirconia polycrystal [Y-TZP] and polyetheretherketone [PEEK]). Each solid was imported to computer-aided engineering software, and tetrahedral elements formed the mesh.

Functional or Nonfunctional Cusps Preservation for Molars Restored with Indirect Composite or Glass-Ceramic Onlays: 3D FEA Study.

Evidence regarding the effect of the onlay preparation design for different CAD/CAM restorative materials considering the preservation of cusps is lacking. Molars were 3D-modeled in four preparation designs for onlay restoration: traditional design with functional cusp coverage (TFC), non-retentive design with functional cusp coverage (NFC), traditional design with non-functional cusp coverage (TNFC) and non-retentive design with non-functional cusp coverage (NNFC). The restorations were simulated with two CAD/CAM restorative materials: LD-lithium disilicate (IPS e.